From Wikipedia, the free encyclopedia
British virologist
Ervin Fodor is a British
virologist of Hungarian origin born in
Czechoslovakia . He is Professor of Virology holding the position of reader in experimental pathology in the
Sir William Dunn School of Pathology at the
University of Oxford . He is also a professorial fellow at
Exeter College, Oxford .
Education
Fodor has an
MSc in
Chemical Engineering (
Slovak University of Technology in Bratislava ) and a
DPhil in
Pathology (
University of Oxford ).
[1]
[2]
Career
After postdoctoral studies at the
Icahn School of Medicine at Mount Sinai New York and the
Sir William Dunn School of Pathology at the
University of Oxford , Fodor has been awarded a
MRC Senior Non-Clinical Research Fellowship in 2002 followed by a
RCUK Academic Fellowship in 2008.
[2]
He was appointed as university lecturer in 2011 and then as reader at the
University of Oxford with the title of professor of virology.
[2]
Fodor's research focuses on the molecular biology of
influenza viruses .
[3]
[4]
[5] An early highlight of his work was the development of a
reverse genetics system to generate recombinant influenza viruses following
plasmid transfection.
[6] This technology, developed in collaboration with
Peter Palese and
Adolfo García-Sastre at the
Icahn School of Medicine and
George Brownlee at the
University of Oxford , was then used to generate live attenuated influenza virus vaccines that are also used in the UK National Childhood Flu Immunisation Programme.
[7] His more recent work focuses on the molecular mechanisms used by influenza viruses to copy their
genetic information stored in molecules of
RNA , interactions of influenza viruses with the host cell and cellular responses to viral infection.
[8]
[9]
[10] In collaboration with
Jonathan Grimes from the
Division of Structural Biology at the University of Oxford he contributed to understanding the structural basis of influenza virus RNA synthesis by solving structures of the influenza virus RNA polymerase complex.
[11]
[12]
[13]
[14]
He is the recipient of the 2019 AstraZeneca Award from the
Biochemical Society .
[15] The award was presented on 20–22 November 2019 in
London, UK
[16] at the meeting of the
Biochemical Society entitled‘Transcriptions in Health and Disease ’ where Fodor delivered a lecture entitled 'The influenza virus RNA polymerase'.
Fodor is a fellow of the
Academy of Medical Sciences
[17] and was elected as a member of
EMBO in 2021.
[18]
[19]
References
^
"ORCID" . orcid.org . Retrieved 12 November 2021 .
^
a
b
c
"Professor Ervin Fodor" . Exeter College . Retrieved 25 January 2023 .
^ Te Velthuis, Aartjan J. W.; Fodor, Ervin (August 2016).
"Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis" . Nature Reviews. Microbiology . 14 (8): 479–493.
doi :
10.1038/nrmicro.2016.87 .
ISSN
1740-1534 .
PMC
4966622 .
PMID
27396566 .
^ Te Velthuis, Aartjan J. W.; Grimes, Jonathan M.; Fodor, Ervin (May 2021).
"Structural insights into RNA polymerases of negative-sense RNA viruses" . Nature Reviews. Microbiology . 19 (5): 303–318.
doi :
10.1038/s41579-020-00501-8 .
ISSN
1740-1534 .
PMC
7832423 .
PMID
33495561 .
^
"Ervin Fodor : Influenza virus replication at the molecular level" . University of Oxford Medical Sciences Division . Retrieved 25 January 2023 .
^ Fodor, E.; Devenish, L.; Engelhardt, O. G.; Palese, P.; Brownlee, G. G.; García-Sastre, A. (November 1999).
"Rescue of influenza A virus from recombinant DNA" . Journal of Virology . 73 (11): 9679–9682.
doi :
10.1128/JVI.73.11.9679-9682.1999 .
ISSN
0022-538X .
PMC
113010 .
PMID
10516084 .
^
"REF Case study search" . impact.ref.ac.uk . Retrieved 12 November 2021 .
^ Te Velthuis, Aartjan J. W.; Robb, Nicole C.; Kapanidis, Achillefs N.; Fodor, Ervin (21 March 2016).
"The role of the priming loop in influenza A virus RNA synthesis" . Nature Microbiology . 1 (5): 16029.
doi :
10.1038/nmicrobiol.2016.29 .
ISSN
2058-5276 .
PMC
4888940 .
PMID
27572643 .
^ Te Velthuis, Aartjan J. W.; Long, Joshua C.; Bauer, David L. V.; Fan, Rebecca L. Y.; Yen, Hui-Ling; Sharps, Jane; Siegers, Jurre Y.; Killip, Marian J.; French, Hollie; Oliva-Martín, Maria José; Randall, Richard E. (November 2018).
"Mini viral RNAs act as innate immune agonists during influenza virus infection" . Nature Microbiology . 3 (11): 1234–1242.
doi :
10.1038/s41564-018-0240-5 .
ISSN
2058-5276 .
PMC
6203953 .
PMID
30224800 .
^ Dadonaite, Bernadeta; Gilbertson, Brad; Knight, Michael L.; Trifkovic, Sanja; Rockman, Steven; Laederach, Alain; Brown, Lorena E.; Fodor, Ervin; Bauer, David L. V. (November 2019).
"The structure of the influenza A virus genome" . Nature Microbiology . 4 (11): 1781–1789.
doi :
10.1038/s41564-019-0513-7 .
ISSN
2058-5276 .
PMC
7191640 .
PMID
31332385 .
^ Hengrung, Narin; El Omari, Kamel; Serna Martin, Itziar; Vreede, Frank T.; Cusack, Stephen; Rambo, Robert P.; Vonrhein, Clemens; Bricogne, Gérard; Stuart, David I.; Grimes, Jonathan M.; Fodor, Ervin (26 October 2015).
"Crystal structure of the RNA-dependent RNA polymerase from influenza C virus" . Nature . 527 (7576): 114–117.
Bibcode :
2015Natur.527..114H .
doi :
10.1038/nature15525 .
ISSN
0028-0836 .
PMC
4783868 .
PMID
26503046 .
^ Serna Martin, Itziar; Hengrung, Narin; Renner, Max; Sharps, Jane; Martínez-Alonso, Mónica; Masiulis, Simonas; Grimes, Jonathan M.; Fodor, Ervin (18 October 2018).
"A Mechanism for the Activation of the Influenza Virus Transcriptase" . Molecular Cell . 72 (2): 396.
doi :
10.1016/j.molcel.2018.10.005 .
ISSN
1097-4164 .
PMC
6201736 .
PMID
30340026 .
^ Fan, Haitian; Walker, Alexander P.; Carrique, Loïc; Keown, Jeremy R.; Serna Martin, Itziar; Karia, Dimple; Sharps, Jane; Hengrung, Narin; Pardon, Els; Steyaert, Jan; Grimes, Jonathan M. (September 2019).
"Structures of influenza A virus RNA polymerase offer insight into viral genome replication" . Nature . 573 (7773): 287–290.
Bibcode :
2019Natur.573..287F .
doi :
10.1038/s41586-019-1530-7 .
ISSN
1476-4687 .
PMC
6795553 .
PMID
31485076 .
^ Carrique, Loïc; Fan, Haitian; Walker, Alexander P.; Keown, Jeremy R.; Sharps, Jane; Staller, Ecco; Barclay, Wendy S.; Fodor, Ervin; Grimes, Jonathan M. (November 2020).
"Host ANP32A mediates the assembly of the influenza virus replicase" . Nature . 587 (7835): 638–643.
Bibcode :
2020Natur.587..638C .
doi :
10.1038/s41586-020-2927-z .
ISSN
1476-4687 .
PMC
7116770 .
PMID
33208942 .
^
"Ervin Fodor honoured with the 2019 AstraZeneca Award | Sir William Dunn School of Pathology" . www.path.ox.ac.uk . Retrieved 25 May 2021 .
^
"The AstraZeneca Award" . Biochemistry . Retrieved 25 May 2021 .
^
"Professor Ervin Fodor is Elected Fellow of the Academy of Medical Sciences | Sir William Dunn School of Pathology" . www.path.ox.ac.uk . Retrieved 25 May 2021 .
^
"Professor Ervin Fodor Elected as Member of EMBO | Sir William Dunn School of Pathology" . www.path.ox.ac.uk . Retrieved 12 November 2021 .
^
"EMBO announces 64 newly elected members – Press releases – EMBO" . 8 June 2021. Retrieved 12 November 2021 .
External links
International Academics Other