Ecdysterone has been tested on mammals due to the interest in its potential hypertrophic effect. It has been found to increase hypertrophy in rats at a similar level to some
anabolic androgenic steroids and
SARM S 1.[8] This is proposed to be through increase of Calcium leading to activation of Akt and protein synthesis in skeletal muscles.[9]
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10.1016/j.jinsphys.2006.02.003.
PMID16580015.
^Dinan L, Savchenko T, Whiting P (July 2001). "On the distribution of phytoecdysteroids in plants". Cellular and Molecular Life Sciences. 58 (8): 1121–1132.
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PMID11529504.
S2CID8496934.