From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
ER degradation-enhancing alpha-mannosidase-like 1 is an
enzyme that in humans is encoded by the EDEM1
gene .
[5]
[6]
References
Further reading
Nagase T, Seki N, Ishikawa K, et al. (1997).
"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain" . DNA Res . 3 (5): 321–9, 341–54.
doi :
10.1093/dnares/3.5.321 .
PMID
9039502 .
Hosokawa N, Wada I, Hasegawa K, et al. (2001).
"A novel ER alpha-mannosidase-like protein accelerates ER-associated degradation" . EMBO Rep . 2 (5): 415–22.
doi :
10.1093/embo-reports/kve084 .
PMC
1083879 .
PMID
11375934 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Oda Y, Hosokawa N, Wada I, Nagata K (2003). "EDEM as an acceptor of terminally misfolded glycoproteins released from calnexin". Science . 299 (5611): 1394–7.
doi :
10.1126/science.1079181 .
PMID
12610305 .
S2CID
28716209 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Olivari S, Galli C, Alanen H, et al. (2005).
"A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation" . J. Biol. Chem . 280 (4): 2424–8.
doi :
10.1074/jbc.C400534200 .
PMID
15579471 .
Oda Y, Okada T, Yoshida H, et al. (2006).
"Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation" . J. Cell Biol . 172 (3): 383–93.
doi :
10.1083/jcb.200507057 .
PMC
2063648 .
PMID
16449189 .
Hosokawa N, Wada I, Natsuka Y, Nagata K (2006).
"EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded alpha1-antitrypsin" . Genes Cells . 11 (5): 465–76.
doi :
10.1111/j.1365-2443.2006.00957.x .
PMID
16629899 .
S2CID
19832510 .
Ewing RM, Chu P, Elisma F, et al. (2007).
"Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89.
doi :
10.1038/msb4100134 .
PMC
1847948 .
PMID
17353931 .
Zuber C, Cormier JH, Guhl B, et al. (2007).
"EDEM1 reveals a quality control vesicular transport pathway out of the endoplasmic reticulum not involving the COPII exit sites" . Proc. Natl. Acad. Sci. U.S.A . 104 (11): 4407–12.
Bibcode :
2007PNAS..104.4407Z .
doi :
10.1073/pnas.0700154104 .
PMC
1810509 .
PMID
17360537 .