From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Dynein axonemal light chain 1, (LC1) is a
protein that in humans is encoded by the DNAL1
gene.
[5]
[6]
Function
LC1 is a component of outer
dynein arms, which contain the molecular motors for
ATP-dependent
cilia movement.
[5]
[6]
Clinical significance
Mutations in the DNAL1 gene are associated with
primary ciliary dyskinesia.
[7]
References
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000119661 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000042523 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^
a
b
"Entrez Gene: dynein".
- ^
a
b Horváth J, Fliegauf M, Olbrich H, Kispert A, King SM, Mitchison H, Zariwala MA, Knowles MR, Sudbrak R, Fekete G, Neesen J, Reinhardt R, Omran H (July 2005).
"Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients". Am. J. Respir. Cell Mol. Biol. 33 (1): 41–7.
doi:
10.1165/rcmb.2004-0335OC.
PMID
15845866.
S2CID
19776274.
-
^ Lancaster MA, Gleeson JG (June 2009).
"The primary cilium as a cellular signaling center: lessons from disease". Curr. Opin. Genet. Dev. 19 (3): 220–9.
doi:
10.1016/j.gde.2009.04.008.
PMC
2953615.
PMID
19477114.
External links
This article incorporates text from the
United States National Library of Medicine, which is in the
public domain.