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Comment: Seems to be notable, please provide citations for the Honors and awards section (for each listing). Also move inline citations after the punctuations (periods .)
X (
talk ) 01:56, 14 May 2024 (UTC)
Katerina Heran Darwin (née Hong) is a Korean-American
microbiologist and Professor of Microbiology at
New York University
Grossman School of Medicine .
[1] Her research interests include the
bacterial proteasome
[2] and the antimicrobial effects of host-produced
effectors including
nitric oxide ,
[3]
[4]
copper ,
[5]
[6]
[7] and
aldehydes
[8] .
Education and academic career
Darwin received a bachelor's degree in microbiology and molecular genetics in 1992 and a PhD in microbiology and molecular genetics in 1999, both from the
University of California, Los Angeles .
[1] Darwin earned her PhD studying
type III secretion in
Salmonella typhimurium with
Virginia Miller ,
[9] who moved her lab to
Washington University in St. Louis ,
MO . Darwin remained with Miller for postdoctoral training before joining the lab of
Carl Nathan at
Weill Medical College of Cornell University (now Weill Cornell Medicine) in
New York, New York .
Darwin joined the faculty of Microbiology at
New York University Grossman School of Medicine in 2004.
[1] Darwin is a fellow of the
American Academy of Microbiology
[10]
[11] since 2016 and was elected to the US
National Academy of Sciences in 2024.
[12]
Research
Darwin has dedicated her career to studying infectious
bacteria , in particular,
Mycobacterium tuberculosis ,
[13] the bacterium responsible for
tuberculosis in humans. Darwin focuses on the characterization of the M. tuberculosis
proteasome ,
[2] a protease complex that is key to lethal infections by M. tuberculosis and helps protect the bacterium from the
innate immune defenses of the host. While characterizing the
mycobacterial proteasome, Darwin's group identified the first known protein-on-protein,
post-translational modification in prokaryotes called Pup (
prokaryotic ubiquitin-like protein ).
[14] While functionally similar to eukaryotic
ubiquitin , Pup's distinct biochemistry makes it a potentially attractive
drug target .
[15]
Darwin and her collaborators are currently investigating the extent to which host-derived
aldehydes may contribute to infection control.
[8]
Honors and awards
2006 Interscience Conference on Antimicrobial Agents and Chemotherapy Young Investigator Award
2009 Awardee, Burroughs Wellcome Fund Investigators in the Pathogenesis of Infectious Disease
[16]
2010 Awardee, Irma T. Hirschl Charitable Trust
[17]
2012 Kavli / National Academy of Sciences Fellow
[18]
2016 Fellow, American Academy of Microbiology
[10]
[11]
2023 NIH Director's Wednesday Afternoon Lecture Series (WALS), Bethesda, MD
[19]
2024
Samsung Ho-Am Prize for Chemistry and Life Sciences
[20]
2024 Elected to the
National Academy of Sciences , USA
[12]
References
^
a
b
c
"Heran Darwin" . med.nyu.edu . Retrieved 2024-05-12 .
^
a
b Jastrab, Jordan B.; Wang, Tong; Murphy, J. Patrick; Bai, Lin; Hu, Kuan; Merkx, Remco; Huang, Jessica; Chatterjee, Champak; Ovaa, Huib; Gygi, Steven P.; Li, Huilin; Darwin, K. Heran (2015-03-23).
"An adenosine triphosphate-independent proteasome activator contributes to the virulence of Mycobacterium tuberculosis " . Proceedings of the National Academy of Sciences . 112 (14): E1763-72.
Bibcode :
2015PNAS..112E1763J .
doi :
10.1073/pnas.1423319112 .
ISSN
0027-8424 .
PMC
4394314 .
PMID
25831519 .
^ Samanovic, Marie I.; Tu, Shengjiang; Novák, Ondřej; Iyer, Lakshminarayan M.; McAllister, Fiona E.; Aravind, L.; Gygi, Steven P.; Hubbard, Stevan R.; Strnad, Miroslav; Darwin, K. Heran (March 2015).
"Proteasomal Control of Cytokinin Synthesis Protects Mycobacterium tuberculosis against Nitric Oxide" . Molecular Cell . 57 (6): 984–994.
doi :
10.1016/j.molcel.2015.01.024 .
ISSN
1097-2765 .
PMC
4369403 .
PMID
25728768 .
^ Darwin, K. Heran; Ehrt, Sabine; Gutierrez-Ramos, José-Carlos; Weich, Nadine; Nathan, Carl F. (2003-12-12).
"The Proteasome of Mycobacterium tuberculosis Is Required for Resistance to Nitric Oxide" . Science . 302 (5652): 1963–1966.
Bibcode :
2003Sci...302.1963D .
doi :
10.1126/science.1091176 .
ISSN
0036-8075 .
PMID
14671303 .
^ Festa, Richard A.; Jones, Marcus B.; Butler-Wu, Susan; Sinsimer, Daniel; Gerads, Russell; Bishai, William R.; Peterson, Scott N.; Darwin, K. Heran (2010-10-29).
"A novel copper-responsive regulon in Mycobacterium tuberculosis " . Molecular Microbiology . 79 (1): 133–148.
doi :
10.1111/j.1365-2958.2010.07431.x .
ISSN
0950-382X .
PMC
3052634 .
PMID
21166899 .
^ Limón, Gina; Samhadaneh, Nora M.; Pironti, Alejandro; Darwin, K. Heran (2022-10-02).
"Aldehyde inactivation of the RicR regulon sensitizesMycobacterium tuberculosis to copper" . dx.doi.org .
doi :
10.1101/2022.09.30.510424 . Retrieved 2024-05-12 .
^ Shi, Xiaoshan; Festa, Richard A.; Ioerger, Thomas R.; Butler-Wu, Susan; Sacchettini, James C.; Darwin, K. Heran; Samanovic, Marie I. (2014-02-28).
"The Copper-Responsive RicR Regulon Contributes to Mycobacterium tuberculosis Virulence" . mBio . 5 (1).
doi :
10.1128/mbio.00876-13 .
ISSN
2161-2129 .
PMC
3944814 .
PMID
24549843 .
^
a
b Darwin, K. Heran; Stanley, Sarah A. (April 2022).
"The aldehyde hypothesis: metabolic intermediates as antimicrobial effectors" . Open Biology . 12 (4).
doi :
10.1098/rsob.220010 .
ISSN
2046-2441 .
PMC
9006002 .
PMID
35414258 .
^ Darwin, K. Heran; Miller, Virginia L. (July 1999).
"Molecular Basis of the Interaction of Salmonella with the Intestinal Mucosa" . Clinical Microbiology Reviews . 12 (3): 405–428.
doi :
10.1128/CMR.12.3.405 .
ISSN
0893-8512 .
PMC
100246 .
PMID
10398673 .
^
a
b
"American Academy of Microbiology" . ASM.org . Retrieved 2024-05-12 .
^
a
b
"K. Heran Darwin, Ph.D." ASM.org . Retrieved 2024-05-12 .
^
a
b Communications, NYU Web.
"Two NYU Faculty Elected to the National Academy of Sciences" . www.nyu.edu . Retrieved 2024-05-12 .
^
"K Heran Darwin" . scholar.google.com . Retrieved 2024-05-12 .
^ Pearce, Michael J.; Mintseris, Julian; Ferreyra, Jessica; Gygi, Steven P.; Darwin, K. Heran (2008-11-14).
"Ubiquitin-Like Protein Involved in the Proteasome Pathway of Mycobacterium tuberculosis " . Science . 322 (5904): 1104–1107.
Bibcode :
2008Sci...322.1104P .
doi :
10.1126/science.1163885 .
ISSN
0036-8075 .
PMC
2698935 .
PMID
18832610 .
^ Darwin, K. Heran (July 2009).
"Prokaryotic ubiquitin-like protein (Pup), proteasomes and pathogenesis" . Nature Reviews Microbiology . 7 (7): 485–491.
doi :
10.1038/nrmicro2148 .
ISSN
1740-1534 .
PMC
3662484 .
PMID
19483713 .
^
"Grant Recipients" . Burroughs Wellcome Fund . Retrieved 2024-05-15 .
^
https://research.weill.cornell.edu/sites/default/files/irma_t._hirschl_trust-mwc_-_award_recipients_12-30-19_.pdf
^
"Heran Darwin" . www.nasonline.org . Retrieved 2024-05-15 .
^
"NIH Director's Wednesday Afternoon Lecture Series 2023-2024 | NIH Office of Intramural Research" . oir.nih.gov . Retrieved 2024-05-15 .
^
"2024 Laureates - HOAM" . www.hoamfoundation.org . Retrieved 2024-05-15 .