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German chemical biologist
Dorothea Fiedler is a
chemical biologist and also the first female director of the
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (Leibniz Research Institute for Molecular Pharmacology, FMP) in
Berlin, Germany .
Early life and education
Fiedler grew up in
Hamburg .
[1] She studied inorganic chemistry at the
University of Würzburg ,
[2] then carried out doctorate research on
organometallic chemistry at the
University of California at Berkeley .
[1]
[3]
Research and career
Although her PhD research focussed on organometallic chemistry
[4]
[5] including host-guest systems and applications to catalysis,
[6]
[7] Fiedler became interested in
cellular signal transduction pathways during her postdoctoral research at the
University of California, San Francisco .
[1]
[8] She started her independent career as an assistant professor at
Princeton University in 2010.
[9] Her research focuses on the synthesis and signalling roles of
inositol phosphates ,
[10] in particular, those with a
pyrophosphate functionality,
[11]
[12]
[13]
[14] which has relevance to cellular signalling and cancer biology.
[15]
[16]
In 2015, Fiedler became the director of the
Leibniz-Forschungsinstitut für Molekulare Pharmakologie as well as a professor of chemistry at the
Humboldt University of Berlin .
[17] She continues developing her research focus on the synthesis and signalling roles of
protein modifications involving pyrophosphates,
[18]
[19] as well as building collaborations on biological chemistry and catalysis.
[20]
Funding, service, and awards
Fiedler has received a New Innovator Award totalling over $2 million from the
NIH in 2013.
[21] She also received funding from the
Sidney Kimmel Foundation for Cancer Research
[22]
[23] and the Rita Allen Foundation.
[24] During her postdoctoral research, she received the
Ernst Schering Foundation Postdoctoral Fellowship, was on the Fastrack Program of the
Robert Bosch Foundation , and obtained an NIH Pathway to Independence Award.
[25]
Fiedler is an invited speaker at the
EMBO conference on
Chemical Biology 2016
[26] and at the International Symposium on
Bioorganic Chemistry in 2017.
[27]
Fiedler is one of the local organizers of the 42nd National Organic Chemistry Symposium by the
organic division of the American Chemical Society in 2011.
[28]
References
^
a
b
c
"FMP Berlin: Dorothea Fiedler is a new director at the FMP" . www.leibniz-fmp.de . 2015-07-14. Retrieved 2019-03-07 . [
permanent dead link ]
^
"Dorothea Fiedler, Chemie, Humboldt-Universität Berlin" . www.uni-wuerzburg.de (in German). Retrieved 2019-03-17 . [
permanent dead link ]
^
"Dorothea Fiedler | Gesellschaft Deutscher Chemiker e.V." www.gdch.de . Retrieved 2023-08-26 .
^ Fiedler, Dorothea; Pagliero, Daniela; Brumaghim, Julia L.; Bergman, Robert G.; Raymond, Kenneth N. (2004-01-15). "Encapsulation of Cationic Ruthenium Complexes into a Chiral Self-Assembled Cage". Inorganic Chemistry . 43 (3): 846–848.
doi :
10.1021/ic035105s .
ISSN
0020-1669 .
PMID
14753801 .
^ Fiedler, Dorothea; Leung, Dennis H.; Bergman, Robert G.; Raymond, Kenneth N. (2004-03-06). "Enantioselective Guest Binding and Dynamic Resolution of Cationic Ruthenium Complexes by a Chiral Metal−Ligand Assembly". Journal of the American Chemical Society . 126 (12): 3674–3675.
doi :
10.1021/ja039225a .
ISSN
0002-7863 .
PMID
15038695 .
^ Fiedler, Dorothea; van Halbeek, Herman; Bergman, Robert G.; Raymond, Kenneth N. (2006-07-19). "Supramolecular Catalysis of Unimolecular Rearrangements: Substrate Scope and Mechanistic Insights". Journal of the American Chemical Society . 128 (31): 10240–10252.
doi :
10.1021/ja062329b .
ISSN
0002-7863 .
PMID
16881654 .
^ Fiedler, Dorothea; Leung, Dennis H.; Bergman, Robert G.; Raymond, Kenneth N. (2005-04-01). "Selective Molecular Recognition, C−H Bond Activation, and Catalysis in Nanoscale Reaction Vessels". Accounts of Chemical Research . 38 (4): 349–358.
CiteSeerX
10.1.1.455.402 .
doi :
10.1021/ar040152p .
ISSN
0001-4842 .
PMID
15835881 .
S2CID
2954569 .
^ Fiedler, Dorothea; Braberg, Hannes; Mehta, Monika; Chechik, Gal; Cagney, Gerard; Mukherjee, Paromita; Silva, Andrea C.; Shales, Michael; Collins, Sean R. (2009-03-05).
"Functional Organization of the S. cerevisiae Phosphorylation Network" . Cell . 136 (5): 952–963.
doi :
10.1016/j.cell.2008.12.039 .
PMC
2856666 .
PMID
19269370 .
^
Princeton Alumni Weekly . princeton alumni weekly. 2009-06-10.
^
"Research - Fiedler Group" . www.princeton.edu . Archived from
the original on 2015-09-06. Retrieved 2019-03-17 .
^ Campbell, Meghan (2015-02-05).
"Lost in Post-Translation :: ChemViews Magazine :: ChemistryViews" . www.chemistryviews.org . Retrieved 2019-03-17 .
^ Wu, Mingxuan; Dul, Barbara E.; Trevisan, Alexandra J.; Fiedler, Dorothea (2013).
"Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers" . Chem. Sci . 4 (1): 405–410.
doi :
10.1039/C2SC21553E .
ISSN
2041-6520 .
PMC
3558982 .
PMID
23378892 .
^ Williams, Florence J.; Fiedler, Dorothea (2015-09-18). "A Fluorescent Sensor and Gel Stain for Detection of Pyrophosphorylated Proteins". ACS Chemical Biology . 10 (9): 1958–1963.
doi :
10.1021/acschembio.5b00256 .
ISSN
1554-8929 .
PMID
26061479 .
^ Marmelstein, Alan M.; Yates, Lisa M.; Conway, John H.; Fiedler, Dorothea (2014-01-08).
"Chemical Pyrophosphorylation of Functionally Diverse Peptides" . Journal of the American Chemical Society . 136 (1): 108–111.
doi :
10.1021/ja411737c .
ISSN
0002-7863 .
PMC
3992712 .
PMID
24350643 .
^ Shears, Stephen B. (2014-10-05).
"Inositol pyrophosphates: Why so many phosphates?" . Advances in Biological Regulation . 57 : 203–216.
doi :
10.1016/j.jbior.2014.09.015 .
PMC
4291286 .
PMID
25453220 .
^ Shah, Akruti; Ganguli, Shubhra; Sen, Jayraj; Bhandari, Rashna (2017-02-28).
"Inositol Pyrophosphates: Energetic, Omnipresent and Versatile Signalling Molecules" . Journal of the Indian Institute of Science . 97 (1): 23–40.
doi :
10.1007/s41745-016-0011-3 .
ISSN
0970-4140 .
PMC
7081659 .
PMID
32214696 .
^
"Humboldt-Universität zu Berlin - Dorothea Fiedler" . agnes.hu-berlin.de . Retrieved 2019-03-17 .
^ Yates, Lisa M.; Fiedler, Dorothea (2016-04-15). "A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins". ACS Chemical Biology . 11 (4): 1066–1073.
doi :
10.1021/acschembio.5b00972 .
ISSN
1554-8929 .
PMID
26760216 .
^ Marmelstein, Alan M.; Morgan, Jeremy A. M.; Penkert, Martin; Rogerson, Daniel T.; Chin, Jason W.; Krause, Eberhard; Fiedler, Dorothea (2018).
"Pyrophosphorylation via selective phosphoprotein derivatization" . Chemical Science . 9 (27): 5929–5936.
doi :
10.1039/C8SC01233D .
ISSN
2041-6520 .
PMC
6050540 .
PMID
30079207 .
^
"UniSysCat: Signal-controlled multicomponent catalysis" . www.unisyscat.tu-berlin.de . Archived from
the original on 2021-04-13. Retrieved 2019-03-17 .
^ Fiedler, Dorothea (2013).
"Understanding phosphate metabolism in cancer and metastasis" . Grantome . Retrieved 2019-03-17 .
^
"The Sidney Kimmel Foundation for Cancer Research Announces 2013 Grant Recipients" . PRWeb . Retrieved 2019-03-17 .
^
"Our Scholars" . Sidney Kimmel Foundation . Retrieved 2019-03-17 .
^
"Years 2013 - Rita Allen Foundation" . Retrieved 2019-03-17 .
^
"UniSysCat: Fiedler, Dorothea" . www.unisyscat.tu-berlin.de . Archived from
the original on 2021-04-13. Retrieved 2019-03-17 .
^
"EMBO Conference - Chemical Biology 2016 - Speakers" . www.embl.de . Retrieved 2019-03-17 .
^
"Speakers | Programme | International Symposium on Bioorganic Chemistry (ISBOC-11) & Konstanz Symposium Chemical Biology | University of Konstanz" . www.uni-konstanz.de . Retrieved 2019-03-17 . [
permanent dead link ]
^
"- NOS History" . ACS Division of Organic Chemistry . 4 November 2016. Retrieved 2019-03-17 .
International National Academics