Dock10 shares the same domain arrangement as other members of the DOCK-D/Zizimin subfamily as well as a high level of sequence similarity.[8] It contains a
DHR2 domain that is involved in G protein binding and a
DHR1 domain, which, in some DOCK family proteins, interacts with membrane
phospholipids. Like other DOCK-D subfamily proteins Dock10 contains an
N-terminalPH domain, which, in
Dock9/Zizimin1, mediates recruitment to the
plasma membrane.[9] The DHR2 domain of Dock10 appears to bind to the small G proteins
Cdc42,
TC10 and
TCL although these interactions are of low affinity.[8] The physiological role of Dock10 is poorly characterised, however a study in
lymphocytes has shown that Dock10
expression is upregulated in
B-lymphocytes and
Chronic Lymphocytic Leukemia (CLL) cells in response to the
cytokineIL-4.[7] This suggests that Dock10 may have a role in B-cell activation and
proliferation. Another study identified Dock10 as a protein that was overexpressed in some aggressive
papillary thyroid carcinomas.[10]
^
abYelo E, Bernardo MV, Gimeno L, et al. (July 2008). "Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes". Mol. Immunol. 45 (12): 3411–18.
doi:
10.1016/j.molimm.2008.04.003.
PMID18499258.
Côté JF, Vuori K (2006). "In Vitro Guanine Nucleotide Exchange Activity of DHR-2/DOCKER/CZH2 Domains". Regulators and Effectors of Small GTPases: Rho Family. Methods in Enzymology. Vol. 406. pp. 41–57.
doi:
10.1016/S0076-6879(06)06004-6.
ISBN9780121828110.
PMID16472648.
External links
Overview of all the structural information available in the
PDB for
UniProt: Q96BY6 (Dedicator of cytokinesis protein 10) at the
PDBe-KB.