From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Diacylglycerol O -acyltransferase 2 (DGAT2 ) is a
protein that in humans is encoded by the DGAT2
gene .
[5]
Function
This gene encodes one of two
enzymes which catalyzes the final reaction in the synthesis of
triglycerides in which
diacylglycerol is covalently bound to long chain fatty
acyl-CoAs.
The encoded protein catalyzes this reaction at low concentrations of
magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different
isoforms have been found for this gene.
References
Further reading
Wakimoto K, Chiba H, Michibata H, Seishima M, Kawasaki S, Okubo K, Mitsui H, Torii H, Imai Y (2003). "A novel diacylglycerol acyltransferase (DGAT2) is decreased in human psoriatic skin and increased in diabetic mice". Biochem. Biophys. Res. Commun . 310 (2): 296–302.
doi :
10.1016/j.bbrc.2003.09.015 .
PMID
14521909 .
Ganji SH, Tavintharan S, Zhu D, Xing Y, Kamanna VS, Kashyap ML (2004).
"Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells" . J. Lipid Res . 45 (10): 1835–45.
doi :
10.1194/jlr.M300403-JLR200 .
PMID
15258194 .
Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J (2007).
"Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13" . BMC Genet . 8 : 17.
doi :
10.1186/1471-2156-8-17 .
PMC
1871603 .
PMID
17477860 .
Friedel S, Reichwald K, Scherag A, Brumm H, Wermter AK, Fries HR, Koberwitz K, Wabitsch M, Meitinger T, Platzer M, Biebermann H, Hinney A, Hebebrand J (2007).
"Mutation screen and association studies in the diacylglycerol O-acyltransferase homolog 2 gene (DGAT2), a positional candidate gene for early onset obesity on chromosome 11q13" . BMC Genet . 8 : 17.
doi :
10.1186/1471-2156-8-17 .
PMC
1871603 .
PMID
17477860 .
Payne VA, Au WS, Gray SL, Nora ED, Rahman SM, Sanders R, Hadaschik D, Friedman JE, O'rahilly S, Rochford JJ (2007).
"Sequential regulation of diacylglycerol acyltransferase 2 expression by CAAT/enhancer-binding protein beta (C/EBPbeta) and C/EBPalpha during adipogenesis" . J. Biol. Chem . 282 (29): 21005–14.
doi :
10.1074/jbc.M702871200 .
PMC
2254492 .
PMID
17504763 .
Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV, Farese RV (2007). "Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle". Am. J. Physiol. Endocrinol. Metab . 293 (6): E1772–81.
doi :
10.1152/ajpendo.00158.2007 .
PMID
17940217 .
Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV (2008).
"Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis" . J. Lipid Res . 49 (11): 2283–301.
doi :
10.1194/jlr.R800018-JLR200 .
PMC
3837458 .
PMID
18757836 .
Kantartzis K, Machicao F, Machann J, Schick F, Fritsche A, Häring HU, Stefan N (2009).
"The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans" (PDF) . Clin. Sci . 116 (6): 531–7.
doi :
10.1042/CS20080306 .
PMID
18980578 .
S2CID
24593609 .
Stone SJ, Levin MC, Zhou P, Han J, Walther TC, Farese RV (2009).
"The endoplasmic reticulum enzyme DGAT2 is found in mitochondria-associated membranes and has a mitochondrial targeting signal that promotes its association with mitochondria" . J. Biol. Chem . 284 (8): 5352–61.
doi :
10.1074/jbc.M805768200 .
PMC
2643492 .
PMID
19049983 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .