Desna or Desná may refer to:

• Desná (Jablonec nad Nisou District), a town in the Liberec Region of the Czech Republic
• Dešná (Jindřichův Hradec District), a municipality and village in the South Bohemian Region of the Czech Republic
• Desná (Svitavy District), a municipality and village in the Pardubice Region of the Czech Republic
• Dešná (Zlín District), a municipality and village in the Zlín Region of the Czech Republic
• Desna, Bihar, a village in Nalanda District of Bihar, India
• Desna, Kozelets Raion, a town in Chernihiv Oblast of Ukraine
• Desna, Vinnytsia Oblast, a town in Vinnytsia Oblast of Ukraine

• Desna (river), a river in Russia and Ukraine
• Desna (Vrbas), a river in Bosnia and Herzegovina
• Desna (Guslitsa), a tributary of the Guslitsa, a river in Moscow Oblast, Russia
• Desna (Pakhra), a tributary of the Pakhra, a river in Moscow Oblast, Russia
• Desna (Southern Bug), a tributary of the Southern Bug in Ukraine
• Desná (Kamenice), a tributary of the Kamenice, a river in the Jizera Mountains of the Czech Republic
• White Desná and Black Desná, rivers in the Jizera Mountains of the Czech Republic
• Desná (Morava), river in the Hrubý Jeseník Mountains of the Czech Republic

• R-9 Desna, Russian intercontinental ballistic missile
• FC Desna Chernihiv, a Ukrainian football club based in Chernihiv
• Desná Dam, a former dam, collapsed in 1916

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