Dafachronic acids are steroid hormones activate the nuclear receptor Daf-12/NR1J1 in Caenorhabditis elegans and related organisms, include Δ4-dafachronic acid and Δ7-dafachronic acid. [1] Both are generated by Daf-9/CYP22A1 from respective precursors. [2]
References
- ^ Witting M, Rudloff HC, Thondamal M, Aguilaniu H, Schmitt-Kopplin P (2015). "Fast separation and quantification of steroid hormones Δ4- and Δ7-dafachronic acid in Caenorhabditis elegans". Journal of Chromatography B. 978–979: 118–121. doi: 10.1016/j.jchromb.2014.12.005. PMID 25544008.
- ^ Aguilaniu H, Fabrizio P, Witting M (2016). "The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry". Frontiers in Endocrinology. 7: 12. doi: 10.3389/fendo.2016.00012. PMC 4749721. PMID 26903948.