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Organic compound used as a chelator
DOTAM
Names
IUPAC name
2-[4,7,10-tris(2-amino-2-oxoethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetamide
Other names
TCMC 2,2′,2”,2”’-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetamide 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic amide 1,4,7,10-tetraaza-1,4,7,10-tetra(2-carbamoylmethyl)cyclododecane
Identifiers
ChemSpider
Key: FQIHLPGWBOBPSG-UHFFFAOYSA-N
InChI=1S/C16H32N8O4/c17-13(25)9-21-1-2-22(10-14(18)26)5-6-24(12-16(20)28)8-7-23(4-3-21)11-15(19)27/h1-12H2,(H2,17,25)(H2,18,26)(H2,19,27)(H2,20,28)
NC(CN1CCN(CC(N)=O)CCN(CC(N)=O)CCN(CC(N)=O)CC1)=O
Properties
C 16 H 32 N 8 O 4
Molar mass
400.484 g·mol−1
Appearance
White powder
Soluble (hygroscopic)
Hazards
GHS labelling :
Warning
H315 ,
H319 ,
H335
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
DOTAM (also known as TCMC ) is an organic compound used as a
chelator much like its carboxylic acid
analog
DOTA . A derivative with a reactive linking group of para-isothiocyanatobenzyl attached to the
cyclen ring is also of interest as a
bifunctional chelator (BFC).
[1]
[2]
p-SCN-Bn-DOTAM
^ Brennecke, Benjamin; Wang, Qinghua; Haap, Wolfgang; Grether, Uwe; Hu, Hai-Yu; Nazaré, Marc (2021-04-21).
"DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells" . Bioconjugate Chemistry . 32 (4): 702–712.
doi :
10.1021/acs.bioconjchem.0c00699 .
ISSN
1043-1802 .
PMID
33691062 .
S2CID
232192471 .
^ Stenberg, Vilde Yuli; Larsen, Roy Hartvig; Ma, Li-Wei; Peng, Qian; Juzenas, Petras; Bruland, Øyvind Sverre; Juzeniene, Asta (January 2021).
"Evaluation of the PSMA-Binding Ligand 212Pb-NG001 in Multicellular Tumour Spheroid and Mouse Models of Prostate Cancer" . International Journal of Molecular Sciences . 22 (9): 4815.
doi :
10.3390/ijms22094815 .
PMC
8124365 .
PMID
34062920 .