DNAâtemplated organic synthesis (DTS) is a way to control the
reactivity of synthetic molecules by using nature's
molarityâbased approach. Historically, DTS was used as a model of
prebioticnucleic acid replication. Now however, it is capable of translating
DNA sequences into complex smallâmolecule and
polymer products of multistep
organic synthesis.[1]
Base Editors
The DNA base editors, developed at
Harvard University under
David Liu, allow altering the genomic structure of
DNA. The base editors include BE3, BE4 and ABE7.
BE3 and its later version, BE4 allow to change the
nucleobase C to T and nucleobase G to A. ABE7 allows to change A-T base pairs into G-C base pairs. The system works by rearranging the
atoms in the target base pair and then tricking cells into fixing the other DNA strand to make the change permanent.[2][3][4][5]
References
^Li, Xiaoyu (2004). "DNA-Templated Organic Synthesis: Nature's Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules". Angewandte Chemie International Edition. 43 (37): 4848â4870.
doi:
10.1002/anie.200400656.
PMID15372570.