Cytochrome P450 family 19 subfamily A member 1 is a
protein that in humans is encoded by the CYP19A1
gene.
[5]
Function
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].
Berstein LM, Imyanitov EN, Suspitsin EN, Grigoriev MY, Sokolov EP, Togo A, Hanson KP, Poroshina TE, Vasiljev DA, Kovalevskij AY, Gamajunova VB (February 2001). "CYP19 gene polymorphism in endometrial cancer patients". J. Cancer Res. Clin. Oncol. 127 (2): 135–8.
doi:
10.1007/s004320000200.
PMID11216915.
S2CID31884230.
Tucci S, Futterweit W, Concepcion ES, Greenberg DA, Villanueva R, Davies TF, Tomer Y (January 2001). "Evidence for association of polycystic ovary syndrome in caucasian women with a marker at the insulin receptor gene locus". J. Clin. Endocrinol. Metab. 86 (1): 446–9.
doi:
10.1210/jcem.86.1.7274.
PMID11232039.
Modugno F, Weissfeld JL, Trump DL, Zmuda JM, Shea P, Cauley JA, Ferrell RE (October 2001). "Allelic variants of aromatase and the androgen and estrogen receptors: toward a multigenic model of prostate cancer risk". Clin. Cancer Res. 7 (10): 3092–6.
PMID11595700.
Bulun SE, Yang S, Fang Z, Gurates B, Tamura M, Zhou J, Sebastian S (December 2001). "Role of aromatase in endometrial disease". J. Steroid Biochem. Mol. Biol. 79 (1–5): 19–25.
doi:
10.1016/s0960-0760(01)00134-0.
PMID11850203.
S2CID7642211.
Chen S, Zhou D, Yang C, Okubo T, Kinoshita Y, Yu B, Kao YC, Itoh T (December 2001). "Modulation of aromatase expression in human breast tissue". J. Steroid Biochem. Mol. Biol. 79 (1–5): 35–40.
doi:
10.1016/s0960-0760(01)00132-7.
PMID11850205.
S2CID33879090.