Cronkhite–Canada syndrome is a rare
syndrome characterized by multiple
polyps of the
digestive tract. It is sporadic (i.e. it does not seem to be a
hereditary disease),[1] and it is currently considered acquired[2] and
idiopathic (i.e. cause remains unknown).
About two-thirds of patients are of Japanese descent and the male to female ratio is 3:2.[3] It was characterized in 1955[4][5] by internal medicine physician Leonard Wolsey Cronkhite Jr. and radiologist Wilma Jeanne Canada.[6]
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Diagnosis
There is no specific test to diagnose Cronkhite–Canada syndrome. Diagnosis is based on symptoms and features of the disease.[8]
Management
Nutritional support is fundamental, and may include dietary guidance, supplements, tube feeding, or intravenous solutions.[9] Treatments proposed include
cromolyn sodium and
prednisone,[10] as well as histamine (H2) receptor antagonists or proton pump inhibitors.[9]
References
^Vernia P, Marcheggiano A, Marinaro V, Morabito S, Guzzo I, Pierucci A (October 2005). "Is Cronkhite-Canada Syndrome necessarily a late-onset disease?". Eur J Gastroenterol Hepatol. 17 (10): 1139–41.
doi:
10.1097/00042737-200510000-00022.
PMID16148564.
Rabinowitz, Simon S.; Ebigbo, Nonyelum Erica; et al. (2017-10-20). Cuffari, Carmen; Windle, Mary L.; Piccoli, David A. (eds.).
"Pediatric Cronkite-Canada syndrome". Medscape. Retrieved 2024-01-30.