It has been suggested that copper complexes of anti-inflammatory drugs are more active than the parent drug[3] and produce fewer gastrointestinal
side-effects.[4] In 2008, a
United States patent was issued for the utilization of ibuprofenate complexes (including copper ibuprofenate) as a
wood preservative.[5]
References
^Frazier, D. R.; S. K. Lynch; G. O. Carlisle (1981). "Synthesis and magnetic properties of bis[2-(4-isobutylphenyl)propionato]copper(II)". Journal of Inorganic and Nuclear Chemistry. 43 (11): 2747–2748.
doi:
10.1016/0022-1902(81)80610-0.
^Abuhijleh AL (September 1994). "Mononuclear and binuclear copper(II) complexes of the antiinflammatory drug ibuprofen: synthesis, characterization, and catecholase-mimetic activity". J. Inorg. Biochem. 55 (4): 255–62.
doi:
10.1016/0162-0134(94)85010-0.
PMID7964714.
^Gordijo CR, Barbosa CA, Da Costa Ferreira AM, Constantino VR, de Oliveira Silva D (May 2005). "Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides". J Pharm Sci. 94 (5): 1135–48.
doi:
10.1002/jps.20336.
PMID15793807.
^US patent 7462227, Anderson, Albert Gordon; Feaster, John; Patel, Damini; Scialdone, Mark, "Ibuprofen complexes as wood preservatives", issued 2007-07-26
Further reading
A. Latif, Abuhijleh (1997). "Synthesis and characterization of copper-ibuprofenate complexes with 2,2'-bipyridine and 1,10-phenanthrolines and their hydrolytic activities in phosphate diester cleavage". Polyhedron. 16 (4): 733–740.
doi:
10.1016/0277-5387(96)00214-8.