Cnksr1

CNKSR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WWV
Identifiers
Aliases	CNKSR1, CNK, CNK1, connector enhancer of kinase suppressor of Ras 1
External IDs	OMIM: 603272; MGI: 2670958; HomoloGene: 4604; GeneCards: CNKSR1; OMA: CNKSR1 - orthologs
Gene location ( Human)
Chr.	Chromosome 1 (human)
End	26,189,884 bp
Gene location ( Mouse)
Chr.	Chromosome 4 (mouse)
End	133,965,710 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; gastrocnemius muscle; ; right lobe of thyroid gland; ; right uterine tube; ; left lobe of thyroid gland; ; body of pancreas; ; mucosa of transverse colon; ; minor salivary glands; ; olfactory zone of nasal mucosa; ; Skeletal muscle tissue of rectus abdominis;
	Top expressed in
	muscle of thigh; ; triceps brachii muscle; ; vastus lateralis muscle; ; temporal muscle; ; gastrocnemius muscle; ; knee joint; ; sternocleidomastoid muscle; ; medial head of gastrocnemius muscle; ; digastric muscle; ; tibialis anterior muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; protein binding;
Cellular component	cytoplasm; plasma membrane; cell cortex; membrane; cell-cell junction;
Biological process	Ras protein signal transduction; Rho protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway;
	Sources: Amigo / QuickGO
Orthologs
	10256
	194231
	ENSG00000142675
	ENSMUSG00000028841
	Q969H4
	A2A9K7
	NM_001297647; NM_001297648; NM_006314
	NM_001081047
	NP_001284576; NP_001284577; NP_006305
	NP_001074516
	Wikidata
View/Edit Human	View/Edit Mouse

Connector enhancer of kinase suppressor of ras 1 is an enzyme that in humans is encoded by the CNKSR1 gene.^[5]^[6]

Function

This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway.^[6]

Interactions

CNKSR1 has been shown to interact with RhoD^[7] and RASSF1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000142675 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028841 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell. 95 (3): 343–53. doi: 10.1016/S0092-8674(00)81766-3. PMID 9814705. S2CID 16587330.
^ ^a ^b "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1".
^ Jaffe AB, Aspenström P, Hall A (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi: 10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
^ Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi: 10.1074/jbc.M401699200. PMID 15075335.

External links

CNKSR1 human gene location in the UCSC Genome Browser.
CNKSR1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000142675 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028841 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9814705-5] Therrien M, Wong AM, Rubin GM (Dec 1998). "CNK, a RAF-binding multidomain protein required for RAS signaling". Cell. 95 (3): 343–53. doi: 10.1016/S0092-8674(00)81766-3. PMID 9814705. S2CID 16587330.

[entrez-6] "Entrez Gene: CNKSR1 connector enhancer of kinase suppressor of Ras 1".

[pmid14749388-7] Jaffe AB, Aspenström P, Hall A (Feb 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Mol. Cell. Biol. 24 (4): 1736–46. doi: 10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.

[pmid15075335-8] Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". J. Biol. Chem. 279 (28): 29247–54. doi: 10.1074/jbc.M401699200. PMID 15075335.

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Function

Interactions

References

Further reading

External links