Drennan grew up in New York with her parents (a medical doctor and anthropologist). She received a bachelor's degree in chemistry from
Vassar College, working in the laboratory of Professor Miriam Rossi.[1] After college, Drennan spent time as high school science and drama teacher, in a quaker run school in Iowa.[2][3] She received her PhD in
biological chemistry from the
University of Michigan in 1995, working in the laboratory of the late Professor
Martha L Ludwig. Drennan's thesis is titled "Crystallographic studies of FMN and Vitamin B12 Dependent Enzymes: Flavodoxin and Methionine Synthase".[4][5]
After her PhD, she joined Douglas Rees as a postdoctoral fellow in the
California Institute of Technology.[6] During her time as a postdoctoral fellow, in 1997, she started and led the undergraduate poster competition at the
American Society for Biochemistry and Molecular Biology (ASBMB) annual meeting. She also served on the ASBMB Education and Professional Development Committee. [7]
Drennan is dyslexic, but believes this has advantages in science, "don't listen to what anyone tells you what you can or cannot do...there is no dyslexia ceiling".[8][9] At high school, Drennan was told "she was probably not even going to graduate high school because of her dyslexia".[10]
Research
Drennan joined the faculty at the
Massachusetts Institute of Technology in 1999. At
Massachusetts Institute of Technology, Drennan focuses on innovation in education and fundamental research.[11] She is interested in the future of college classrooms and creating a positive learning environment for diverse groups of students.[12] She is recognized for her contributions to science pedagogy.[13] In 2006 Drennan was named an HHMI Professor and awarded a $1 million grant to support educational initiatives for "Getting Biologists Excited about Chemistry".[14]
Drennan has studied enzymes that employ
vitamin B12 since she was a graduate student.[15] Her research focus is
metalloproteins and
metalloenzymes, and developing structural approaches to visualize enzymes.[16][17][18] Her group uses
X-ray crystallography and
electron microscopy to characterize
metalloproteins in action.[19][20] She is interested in conformational change during catalysis.[21] Her work also contributes to protecting the environment, as metals act as molecular helpers in chemical reactions.[22] Drennan is the author of over 100 Protein Data Bank submissions.[23]