A rat roundworm Gongylonema neoplasticum was the first parasite discovered—allegedly—to cause cancer. A Danish physician
Johannes Fibiger discovered it in 1907, and experimentally showed that he could induce stomach cancer in rats using the roundworm infection in 1913. In 1914, he gave the name Spiroptera (Gongylonema) neoplastica, but later changed it to Spiroptera carcinoma.[3] Fibiger won the 1926 Nobel Prize in Physiology or Medicine "for his discovery of the Spiroptera carcinoma". However, his interpretation was later found to be false, and that the roundworm was not carcinogenic on its own.[4][5] Fibiger's Nobel Prize was described as "one of the biggest blunders made by the Karolinska Institute."[6]
The first true carcinogenic parasite discovered was Schistosoma haematobium. Theodor Maximillian Bilharz, a German physician at the Kasr el-Aini Hospital in Cairo recovered the adult fluke from a dead soldier in 1851. He named it Distomum haematobium. The disease is often called bilharzia in honour of the discoverer.[7] The infectivity and life cycle was discovered by Scottish physician
Robert Thomson Leiper in 1915.[8] A British Surgeon
Reginald Harrison, at the Liverpool Royal Infirmary, was the first to note its role in cancer. In 1889, he found that four people out of five cancer victims had bilharzia. A German physician Carl Goebel confirmed in 1903 that bladder tumour occurred in most bilharzia patients. By 1905, he was convinced that
carcinoma of bladder was due to bilharzia.[9]
Group 1 carcinogens in human
Three flukes, urinary blood fluke (Schistosoma haematobium), Southeast Asian liver fluke (Opisthorchis viverrini) and Chinese liver fluke (Clonorchis sinensis) are classified as Group 1 carcinogens, i.e. they are substantiated and directly cancer-causing agents.[1]
Schistosoma haematobium
S. haematobium is a
digenetictrematode found in Africa and the Middle East. It is the major agent of
schistosomiasis, the most prevalent parasitic infection in humans.[10] It is the only blood fluke that infects the urinary tract, causing urinary schistosomiasis, and is the leading cause of
bladder cancer (only next to tobacco smoking).[11][12] Its life cycle is transmission between humans and freshwater snail, species of Bulinus. The larvae live in water bodies from where they infect the hosts by penetrating the skin. Adults are found in the
venous plexuses around the
urinary bladder and the released eggs travels to the wall of the urine bladder causing
haematuria and fibrosis of the bladder. The bladder becomes
calcified, and there is increased pressure on ureters and kidneys (
hydronephrosis). Inflammation of the genitals due to S. haematobium may contribute to the propagation of HIV.[13] Antigens produced by the eggs induce
granuloma formation. Granulomata in turn coalesce to form tubercles, nodules or masses that often
ulcerate. This creates the pathological lesions found in the bladder wall, ureter and renal; and also tumour, both
benign and
malignant.[14][15]
Opisthorchis viverrini
O. viverrini is a food-borne liver fluke that mainly attacks the area of the
bile duct. Infection with the parasite, called
opisthorchiasis is the major cause of
cholangiocarcinoma, a cancer of the
bile ducts, in northern Thailand, the Lao People's Democratic Republic, Vietnam and Cambodia.[16]O. viverrini has three successive host for its life cycle – the first intermediate hosts are freshwater snails of the genus
Bithynia, the second intermediate hosts are different cyprinid fish, and humans are the definitive hosts.[17] Generally opisthorchiasis due to O. viverrini is harmless without any clinical symptoms, but in rare cases,
cholangitis,
cholecystitis, and cholangiocarcinoma can develop. O. viverrini invades the bile ducts and, rarely, the gall bladder and pancreatic duct. Heavy infection can produce problems such as fibrosis in the liver, gall bladder and bile ducts.[18] Pathological effects on the bile ducts including inflammation,
epithelial desquamation,
goblet cell metaplasia, epithelial and adenomatous
hyperplasia and periductal fibrosis collectively promote cholangiocarcinoma.[19] Though it is not immediately life-threatening, cancer develops after 30–40 years, and the ensuing death is rapid—within 3–6 months of diagnosis.[20]
Clonorchis sinensis
C. sinensis is also a food-borne liver fluke. It is the most prevalent human trematode in Asia, and is found in Korea, China, Vietnam and also Russia. 85% of the cases are found in China.[21] It is transmitted similarly to O. viverrini, but the species of snails are varied, of which Parafossarulus manchouricus is the most common. The cyprinid fish hosts are also different.[22] General clonorchiasis is indicated with fatigue, abdominal discomfort, anorexia, weight loss, diarrhea,
liver cirrhosis and jaundice. The most severe infections cause
cholangiocarcinoma and
hepatic carcinoma.[23]
Indirect or putative carcinogens
Infection with malarial parasite Plasmodium falciparum is classified by IARC as probable (Group 2A) carcinogen. Schistosoma japonicum is a possible (Group 2B) carcinogen. There is a close association between the cat liver fluke Opisthorchis felineus and bile duct cancer among people in Russia.[24][25]
Toxoplasma gondii and eye cancer (intraocular lymphoma) was detected by PCR from two human cases.[26]Strongyloides stercoralis eggs and adult worms may be linked with gastric adenocarcinoma and colon adenocarcinoma in Korea.[27][2]Cryptosporidium parvum infection is associated with colorectal carcinoma.[28][29]
Carcinogens in animals
The roundworm Trichuris muris infection can increase the number of tumours in mice.[30] Heavy infection with the trematode Platynosomum fastosum is associated with cholangiocarcinoma in cats.[31]Cryptosporidium parvum infection can be the cause of carcinoma in the gut of mice.[29][32]
^Oettlé, A. G. (1962). "A historical review of past histopathological material at the South African Institute for Medical Research between 1911 and 1927". South African Medical Journal. 36 (31): 628–631.
^Clemmesen, J (1978). "Johannes Fibiger. Gongylonema and vitamin A in carcinogenesis". Acta Pathologica et Microbiologica Scandinavica. 270 (Suppl): 1–13.
PMID362817.
^Norrby, Erling (2010). Nobel Prizes and Life Sciences. Singapore: World Scientific Publishing Co. p. 115.
ISBN978-9-81-429937-4.
^Berry, A.; Iriart, X.; Fillaux, J.; Magnaval, J.-F. (2017). "Schistosomose urogénitale et cancer [Urinary schistosomiasis and cancer]". Bulletin de la Société de Pathologie Exotique. 110 (1): 68–75.
doi:
10.1007/s13149-017-0547-4.
PMID28185084.
S2CID195078476.
^Anon (2017).
"Schistosomiasis". WHO Fact Sheet. WHO Media Centre. Retrieved 12 December 2017.
^Antoni, S.; Ferlay, J.; Soerjomataram, I.; Znaor, A.; Jemal, A.; Bray, F. (2017). "Bladder Cancer incidence and mortality: A global overview and recent trends". European Urology. 71 (1): 96–108.
doi:
10.1016/j.eururo.2016.06.010.
PMID27370177.
^Khurana S, Dubey ML, Malla N (April 2005). "Association of parasitic infections and cancers". Indian J Med Microbiol. 23 (2): 74–79.
doi:
10.1016/S0300-483X(01)00357-2.
PMID15928434.
^Mills, E.A.; Machattie, C.; Chadwick, C.R. (1936). "Schistosoma haematobium and its life cycle in Iraq". Transactions of the Royal Society of Tropical Medicine and Hygiene. 30 (3): 317–334.
doi:
10.1016/S0035-9203(36)90068-8.
^Fedorova, Olga S.; Kovshirina, Yulia V.; Kovshirina, Anna E.; Fedotova, Marina M.; Deev, Ivan A.; Petrovskiy, Fedor I.; Filimonov, Aleksandr V.; Dmitrieva, Alla I.; et al. (2017). "Opisthorchis felineus infection and cholangiocarcinoma in the Russian Federation: A review of medical statistics". Parasitology International. 66 (4): 365–371.
doi:
10.1016/j.parint.2016.07.010.
PMID27474689.