Cytokine-like protein 1 (also protein C17) is a
protein that in humans is encoded by the CYTL1gene.[5]
Function
Protein C17 is a
cytokine-like protein specifically expressed in
bone marrow and
cord blood mononuclear cells that bear the
CD34 surface marker.[6] Functionally, C17 was identified as a
secretory protein expressed in CD34+
haemopoietic cells.[6] CYTL1 seems to regulate
chondrogenesis and is required for the maintenance of
cartilage homeostasis and might, additionally, work as a regulatory factor in
embryo implantation in the stage of early pregnancy.[7]
This family of proteins, C17, is found in
vertebrates. Proteins have two conserved
sequence motifs: PPTCYSR and DDC.
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abLiu X, Rapp N, Deans R, Cheng L (May 2000). "Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells". Genomics. 65 (3): 283–92.
doi:
10.1006/geno.2000.6170.
PMID10857752.
Deng X, Zhao HS, Peng Z, Deng WW, Li N, Guo S, Shi TP (April 2011). "[Study on the mechanism of C17orf62 induced cell death]". Beijing da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences. 43 (2): 168–72.
PMID21503106.
Tomczak A, Pisabarro MT (April 2011). "Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model". Proteins. 79 (4): 1277–92.
doi:
10.1002/prot.22963.
PMID21322034.
S2CID24312749.