From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Cleavage stimulation factor 64 kDa subunit is a
protein that in humans is encoded by the CSTF2
gene.
[5]
[6]
This gene encodes a nuclear protein with an RRM (
RNA recognition motif) domain. The protein is a member of the
cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and
polyadenylation of
pre-mRNAs. Specifically, this protein binds GU-rich elements within the
3'-untranslated region of mRNAs.
[6]
Interactions
CSTF2 has been shown to
interact with
CSTF3,
[7]
SUB1,
[8]
SYMPK,
[7]
BARD1
[9]
[10] and
BRCA1.
[9]
[10]
References
- ^
a
b
c
GRCh38: Ensembl release 89: ENSG00000101811 –
Ensembl, May 2017
- ^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031256 –
Ensembl, May 2017
-
^
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
-
^ Takagaki Y, MacDonald CC, Shenk T, Manley JL (March 1992).
"The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs". Proc Natl Acad Sci U S A. 89 (4): 1403–7.
Bibcode:
1992PNAS...89.1403T.
doi:
10.1073/pnas.89.4.1403.
PMC
48459.
PMID
1741396.
- ^
a
b
"Entrez Gene: CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa".
- ^
a
b Takagaki, Y; Manley J L (March 2000).
"Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25.
doi:
10.1128/MCB.20.5.1515-1525.2000.
ISSN
0270-7306.
PMC
85326.
PMID
10669729.
-
^ Calvo, O; Manley J L (May 2001).
"Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell. 7 (5): 1013–23.
doi:
10.1016/S1097-2765(01)00236-2.
ISSN
1097-2765.
PMID
11389848.
- ^
a
b Kleiman, F E; Manley J L (March 2001).
"The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53.
doi:
10.1016/S0092-8674(01)00270-7.
ISSN
0092-8674.
PMID
11257228.
- ^
a
b Kleiman, F E; Manley J L (September 1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50".
Science. 285 (5433): 1576–9.
doi:
10.1126/science.285.5433.1576.
ISSN
0036-8075.
PMID
10477523.
External links
Further reading
- Takagaki Y, Manley JL (1992).
"A human polyadenylation factor is a G protein beta-subunit homologue". J. Biol. Chem. 267 (33): 23471–4.
doi:
10.1016/S0021-9258(18)35861-7.
PMID
1358884.
- Murthy KG, Manley JL (1995).
"The 160-kD subunit of human cleavage-polyadenylation specificity factor coordinates pre-mRNA 3'-end formation". Genes Dev. 9 (21): 2672–83.
doi:
10.1101/gad.9.21.2672.
PMID
7590244.
- Takagaki Y, Manley JL (1994). "A polyadenylation factor subunit is the human homologue of the Drosophila suppressor of forked protein". Nature. 372 (6505): 471–4.
Bibcode:
1994Natur.372..471T.
doi:
10.1038/372471a0.
PMID
7984242.
S2CID
4329672.
- Rüegsegger U, Beyer K, Keller W (1996).
"Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors". J. Biol. Chem. 271 (11): 6107–13.
doi:
10.1074/jbc.271.11.6107.
PMID
8626397.
- Schul W, Groenhout B, Koberna K, et al. (1996).
"The RNA 3' cleavage factors CstF 64 kDa and CPSF 100 kDa are concentrated in nuclear domains closely associated with coiled bodies and newly synthesized RNA". EMBO J. 15 (11): 2883–92.
doi:
10.1002/j.1460-2075.1996.tb00649.x.
PMC
450226.
PMID
8654386.
- Takagaki Y, Seipelt RL, Peterson ML, Manley JL (1997).
"The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation". Cell. 87 (5): 941–52.
doi:
10.1016/S0092-8674(00)82000-0.
PMID
8945520.
- Takagaki Y, Manley JL (1997).
"RNA recognition by the human polyadenylation factor CstF". Mol. Cell. Biol. 17 (7): 3907–14.
doi:
10.1128/MCB.17.7.3907.
PMC
232243.
PMID
9199325.
- Martincic K, Campbell R, Edwalds-Gilbert G, et al. (1998).
"Increase in the 64-kDa subunit of the polyadenylation/cleavage stimulatory factor during the G0 to S phase transition". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11095–100.
Bibcode:
1998PNAS...9511095M.
doi:
10.1073/pnas.95.19.11095.
PMC
21601.
PMID
9736695.
- Takagaki Y, Manley JL (1999).
"Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation". Mol. Cell. 2 (6): 761–71.
doi:
10.1016/S1097-2765(00)80291-9.
PMID
9885564.
- Kleiman FE, Manley JL (1999). "Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50". Science. 285 (5433): 1576–9.
doi:
10.1126/science.285.5433.1576.
PMID
10477523.
- Takagaki Y, Manley JL (2000).
"Complex protein interactions within the human polyadenylation machinery identify a novel component". Mol. Cell. Biol. 20 (5): 1515–25.
doi:
10.1128/MCB.20.5.1515-1525.2000.
PMC
85326.
PMID
10669729.
- Dass B, McMahon KW, Jenkins NA, et al. (2001).
"The gene for a variant form of the polyadenylation protein CstF-64 is on chromosome 19 and is expressed in pachytene spermatocytes in mice". J. Biol. Chem. 276 (11): 8044–50.
doi:
10.1074/jbc.M009091200.
PMID
11113135.
- Kleiman FE, Manley JL (2001).
"The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression". Cell. 104 (5): 743–53.
doi:
10.1016/S0092-8674(01)00270-7.
PMID
11257228.
- Calvo O, Manley JL (2001).
"Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination". Mol. Cell. 7 (5): 1013–23.
doi:
10.1016/S1097-2765(01)00236-2.
PMID
11389848.
- Bléoo S, Sun X, Hendzel MJ, et al. (2002).
"Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA". Mol. Biol. Cell. 12 (10): 3046–59.
doi:
10.1091/mbc.12.10.3046.
PMC
60154.
PMID
11598190.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
Bibcode:
2002PNAS...9916899M.
doi:
10.1073/pnas.242603899.
PMC
139241.
PMID
12477932.
- Pérez Cañadillas JM, Varani G (2003).
"Recognition of GU-rich polyadenylation regulatory elements by human CstF-64 protein". EMBO J. 22 (11): 2821–30.
doi:
10.1093/emboj/cdg259.
PMC
156756.
PMID
12773396.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5.
doi:
10.1038/ng1285.
PMID
14702039.
- Xing H, Mayhew CN, Cullen KE, et al. (2004).
"HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin". J. Biol. Chem. 279 (11): 10551–5.
doi:
10.1074/jbc.M311719200.
PMID
14707147.