From Wikipedia, the free encyclopedia
Protein-coding gene in humans
Centromere protein I is a
protein that in humans is encoded by the CENPI
gene .
[5]
[6]
Function
The product of this gene is involved in the response of gonadal tissues to
follicle-stimulating hormone . This gene is also a potential candidate for human X-linked disorders of gonadal development and
gametogenesis .
[6] CENPI is a target gene of the
transcription factor
E2F .
[7] Additionally, CENPI expression is increased in
breast cancer and this has been shown to cause
chromosome instability in breast cancer cells.
[7]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000102384 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000031262 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology . 8 (5): 446–57.
doi :
10.1038/ncb1396 .
PMID
16622420 .
S2CID
26974412 .
^
a
b
"Entrez Gene: CENPI centromere protein I" .
^
a
b Thangavelu PU, Lin CY, Vaidyanathan S, Nguyen TH, Dray E, Duijf PH (September 2017).
"CENPI promotes chromosome instability and predicts poor prognosis in estrogen receptor-positive breast cancer" . Oncotarget . 8 (37): 62167–62182.
doi :
10.18632/oncotarget.19131 .
PMC
5617495 .
PMID
28977935 .
Further reading
Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006).
"Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells" . Genes to Cells . 11 (6): 673–84.
doi :
10.1111/j.1365-2443.2006.00969.x .
PMID
16716197 .
Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology . 8 (5): 458–69.
doi :
10.1038/ncb1397 .
PMID
16622419 .
S2CID
205286556 .
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006).
"Phosphoproteome analysis of the human mitotic spindle" . Proceedings of the National Academy of Sciences of the United States of America . 103 (14): 5391–6.
Bibcode :
2006PNAS..103.5391N .
doi :
10.1073/pnas.0507066103 .
PMC
1459365 .
PMID
16565220 .
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004).
"Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase" . Genes to Cells . 9 (2): 105–20.
doi :
10.1111/j.1365-2443.2004.00705.x .
PMID
15009096 .
S2CID
21813024 .
Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ (April 2003). "Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis". Nature Cell Biology . 5 (4): 341–5.
doi :
10.1038/ncb953 .
PMID
12640463 .
S2CID
33165992 .
Roberts RG, Kendall E, Vetrie D, Bobrow M (October 1996). "Sequence and chromosomal location of a human homologue of LRPR1, an FSH primary response gene". Genomics . 37 (1): 122–4.
doi :
10.1006/geno.1996.0528 .
PMID
8921378 .
Slegtenhorst-Eegdeman KE, Post M, Baarends WM, Themmen AP, Grootegoed JA (February 1995).
"Regulation of gene expression in Sertoli cells by follicle-stimulating hormone (FSH): cloning and characterization of LRPR1, a primary response gene encoding a leucine-rich protein" . Molecular and Cellular Endocrinology . 108 (1–2): 115–24.
doi :
10.1016/0303-7207(94)03468-9 .
hdl :
1765/64471 .
PMID
7758824 .
S2CID
11122437 .
Adams MD, Dubnick M, Kerlavage AR, Moreno R, Kelley JM, Utterback TR, Nagle JW, Fields C, Venter JC (February 1992). "Sequence identification of 2,375 human brain genes". Nature . 355 (6361): 632–4.
Bibcode :
1992Natur.355..632A .
doi :
10.1038/355632a0 .
PMID
1538749 .
S2CID
4234345 .
External links
Basic concepts Types Processes and evolution Structures
See also