Signal transduction protein CBL-C is a
protein that in humans is encoded by the CBLCgene.[5][6][7]
CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM][7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Keane MM, Ettenberg SA, Nau MM, Banerjee P, Cuello M, Penninger J, Lipkowitz S (Jun 1999). "cbl-3: a new mammalian cbl family protein". Oncogene. 18 (22): 3365–75.
doi:
10.1038/sj.onc.1202753.
PMID10362357.
S2CID28195948.
^
abKim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Dec 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145–54.
doi:
10.1016/S0378-1119(99)00356-X.
PMID10571044.
^Kim M, Tezuka T, Suziki Y, Sugano S, Hirai M, Yamamoto T (Oct 1999). "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1). NETHERLANDS: 145–54.
doi:
10.1016/S0378-1119(99)00356-X.
ISSN0378-1119.
PMID10571044.
Ollendorff V, Mattei M, Fournier E, et al. (1999). "A third human CBL gene is on chromosome 19". Int. J. Oncol. 13 (6): 1159–61.
doi:
10.3892/ijo.13.6.1159.
PMID9824625.
Irby RB, Mao W, Coppola D, et al. (1999). "Activating SRC mutation in a subset of advanced human colon cancers". Nat. Genet. 21 (2): 187–90.
doi:
10.1038/5971.
PMID9988270.
S2CID27129630.
Kim M, Tezuka T, Tanaka K, Yamamoto T (2004). "Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation". Oncogene. 23 (9): 1645–55.
doi:
10.1038/sj.onc.1207298.
PMID14661060.
S2CID24925646.