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Chemotherapy regimen
Pre- and post-chemotherapy images of a T3 N1 M0 cStage IIIa colorectal cancer. Four courses of CAPOX therapy.
CAPOX (also called XELOX
[1] ) is a
chemotherapy regimen consisting of
capecitabine (
trade name Xeloda) combined with
oxaliplatin .
[2]
[3]
Xelox regime operates in 3-week cycles, usually with 8 cycles in total; Xeloda is taken orally twice daily for two weeks, while oxaliplatin is administered by IV on the first day of the cycle; there is a one-week rest period before the next cycle.
Adverse effects
References
^ Cassidy, J.; Tabernero, J.; Twelves, C.; Brunet, R.; Butts, C.; Conroy, T.; Debraud, F.; Figer, A.; Grossmann, J.; Sawada, N.; Schöffski, P.; Sobrero, A.; Van Cutsem, E.; Díaz-Rubio, E. (2004).
"XELOX (Capecitabine Plus Oxaliplatin): Active First-Line Therapy for Patients with Metastatic Colorectal Cancer" . Journal of Clinical Oncology . 22 (11): 2084–2091.
doi :
10.1200/JCO.2004.11.069 .
PMID
15169795 .
^
Capecitabine Combined with Oxaliplatin (CapOx) in Clinical Practice: How Significant is Peripheral Neuropathy? D. J. Storey; M. Sakala; C. M. McLean; H. A. Phillips; L. K. Dawson; L. R. Wall; M. T. Fallon; S. Clive. Posted: 09/28/2010; Annals of Oncology. 2010;21(8):1657-1661. © 2010 Oxford University Press
^ Twelves C, Wong A, Nowacki MP, et al. (June 2005).
"Capecitabine as adjuvant treatment for stage III colon cancer" . N. Engl. J. Med . 352 (26): 2696–704.
doi :
10.1056/NEJMoa043116 .
PMID
15987918 .