Combination of | |
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Butalbital | Barbiturate |
Acetaminophen | Miscellaneous analgesic |
Clinical data | |
Trade names | Allzital, Butapap, Tencon, others |
AHFS/ Drugs.com | Professional Drug Facts |
License data | |
Routes of administration | By mouth |
ATC code | |
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Identifiers | |
CAS Number | |
ChemSpider |
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KEGG |
Combination of | |
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Butalbital | Barbiturate |
Acetaminophen | Miscellaneous analgesic |
Caffeine | Xanthine |
Clinical data | |
Trade names | Anoquan, Fioricet, Triad, others |
AHFS/ Drugs.com | Professional Drug Facts |
MedlinePlus | a601009 |
License data | |
Routes of administration | By mouth |
ATC code |
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KEGG |
Butalbital/acetaminophen, sold under the brand name Butapap among others, is a combination medication used to treat tension headaches and migraine headaches. [1] [4] [5] It contains butalbital, a barbiturate and paracetamol (acetaminophen), an analgesic. [4] Versions also containing caffeine are sold under the brand name Fioricet among others. [6] It is taken by mouth. [4] [3] The combination is also sold with codeine. [7]
The most common side effects include sleepiness, dizziness, trouble breathing, and abdominal pain. [4] Other severe side effects may include liver problems, confusion, addiction, and allergic reactions. [4] Frequent use may result in medication overuse headache. [8] Barbiturate withdrawal may occur if rapidly stopped following long term use. [9] Use is not generally recommended during pregnancy or breastfeeding. [10]
The combination was approved for medical use in the United States in 1984. [4] It is available as a generic medication. [6] In 2021, the combination butalbital/acetaminophen/caffeine was the 232nd most commonly prescribed medication in the United States, with more than 1 million prescriptions. [11] [12] In the United States it is a schedule III controlled substance [2] in some states but not federally. [5] [13] [14] It is banned in a number of European countries. [9]
Butalbital/acetaminophen is indicated for the treatment of tension headaches. [15]
Butalbital/acetaminophen/caffeine is indicated for the treatment of tension headaches. [3]
Commonly reported side effects include euphoria, dizziness or lightheadedness, drowsiness or sedation, intoxication, nausea, vomiting, dependence, shortness of breath, and abdominal pain.[ citation needed]
Prolonged use can cause rebound headaches. [16]
Rarely, use of barbiturates can lead to Stevens–Johnson syndrome. [17]
Butalbital has a half-life of about 35 hours. Acetaminophen has a half-life of about 1.25 to 3 hours, but may be increased by liver damage and after an overdose. Caffeine has a half-life of about 2.5 to 4.5 hours. [18]
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