Generalized bullous fixed drug eruption (GBFDE) most commonly refers to a drug reaction in the
erythema multiforme group.[3]: 129 These are uncommon reactions to medications, with an incidence of 0.4 to 1.2 per million person-years for
toxic epidermal necrolysis and 1.2 to 6.0 per million person-years for
Stevens–Johnson syndrome.[3]: 129 The primary
skin lesions are large erythemas (faintly discernible even after confluence), most often irregularly distributed and of a characteristic purplish-livid color, at times with flaccid blisters.[2]: 554
Signs and symptoms
A rare and severe variation of
fixed drug eruption, generalized bullous fixed drug eruption involves
blisters and erosions involving at least 10% of the body's surface area, affecting three of the six anatomic sites: the head and neck, the anterior and posterior trunk, the upper and lower extremities, and the genitalia.[4]
In cases where the clinical presentation is unclear, a
skin biopsy may be necessary to confirm the diagnosis of GBFDE. A subepidermal blister or denuded epidermis, vacuolar alterations at the dermo-epidermal junction, and a variable number of necrotic
keratinocytes within the lesional intact epidermis are characteristic histopathologic findings of GBFDE.[5]
Treatment
Antihistamines and
topical steroids are used in symptomatic therapy.
Antibiotics should be given if an infection is thought to be present.[6] It is also important to counsel the patient to stay away from the offending medication.[7]