Björn Folkow was born in
Halmstad,
Sweden. He studied medicine at
Lund University where he continued with doctoral studies in
physiology. He defended his thesis on 9 May 1949.[1] Soon thereafter he became associate professor ('laborator') at the new Department of Physiology at the
University of Gothenburg. He became full professor in 1961[2] and remained there until his retirement in 1987. Even after retirement he continued being active in the department until shortly before his death in 2012.[3]
Folkow was a member of the
Royal Swedish Academy of Sciences and member of the
Danish and
Russian Academies of Sciences.[3] The European Society of Hypertension established the Björn Folkow Award and Lecture in 1989.[4]
Scientific activity
Folkow published more than 400 scientific papers, covering most areas of cardiovascular physiology. He was an international authority in the field of
high blood pressure.[5] His main contributions arguably are found in the following areas:
The
myogenic response of blood vessels. In 1902
Bayliss[6] described that many blood vessels respond to an elevation of transmural pressure by constriction, finally reaching a diameter that is smaller than the initial diameter at the lower pressure. This observation, which had not received much attention at the time, was studied by Folkow as part of his thesis work and subsequently for more than a decade. He described this mechanism as an essential element in vascular control. This is now well-established knowledge in cardiovascular physiology.
The structural adaptation of blood vessels to elevated blood pressure. Folkow and coworkers studied the blood flow in the forearm in persons with high blood pressure, finding an elevated resistance to flow even in situations when the blood vessels would be fully dilated.[7] This indicated a structural adaptation of the blood vessels to a state with smaller lumen diameter but thicker wall (what now is termed remodelling[8]). This confers to the vessel wall what corresponds to a longer lever, enabling them to contract against higher pressures. This can be seen as the beginning of a vicious circle, where an elevation of pressure causes remodelling that promotes further pressure elevation. Folkow's description of these vascular alterations[9] has since been verified in a large number of studies.
The role of the central nervous system in cardiovascular control. Possibly as a consequence of Folkow's interest in the interplay between body and mind he became interested in central nervous control of the cardiovascular system.[10] He particularly pointed to the role of the defence-alarm reaction (the
fight-or-flight response) in everyday blood-pressure control. His opinion was that individuals with a tendency to react more strongly with this response tend to develop higher blood pressure, since they more often get blood pressure elevation in response to common stressors. Even though the kidney is important for blood pressure control, he viewed it as subordinate to the brain.
The function of the sympathetic nerve terminals. The
sympathetic nervous system has a central role in blood pressure control. It thus attracted Folkow's attention early on,[10] in particular following the mapping of this system.[3] Combining quantification of the density of adrenergic varicosities in the vascular wall with estimates of noradrenaline release indicated that on average only a few per cent of the transmitter content of a
synaptic vesicle was released from a given nerve terminal by an
action potential in the nerve.[11] It has since been found that transmitter release from a varicosity is intermittent,[12] but whether all or only part of the vesicle's contents is released is still a matter of debate.[13][14][15]
The physiology of aging. Partly because of his contacts with the professor of geriatrics in Gothenburg, Alvar Svanborg, Folkow acquired an interest for the implications of physiological aging in cardiovascular control. This collaboration resulted in a major review article in this field.[16]
Textbook
Circulation[17] This textbook was written by Folkow in collaboration with Eric Neil. It is a thorough description of the essential concepts in this area, and large parts of it remain relevant even today, although for obvious reasons more modern aspects are lacking. A follow-up was planned in the eighties in collaboration with
Paul Korner, but due to differences in opinion on several aspects Folkow withdrew from the collaboration to save their friendship.
References
^Folkow, Björn (1949). Observationer rörande nervösa, kemiska och mekaniska faktorers betydelse för regleringen av de små blodkärlens tonus. Lund: Carl Bloms Boktryckeri. pp. 1–15.
^Folkow, B; Grimby, G; Thulesius, O (1958). "Adaptive structural changes of the vascular walls in hypertension and their relation to the control of the peripheral resistance". Acta Physiol Scand. 44 (3–4): 255–272.
doi:
10.1111/j.1748-1716.1958.tb01626.x.
PMID13617022.