Aspidospermidine is an
alkaloid isolated from plants in the genus Aspidosperma.[1] It has been a popular target for
total synthesis,[2][3][4][5] due in part to the fact that it provides a good showcase for synthetic strategies but also because the structure is similar to many other important bioactive molecules.[6]
References
^Deutsch, Harold F.; Evenson, Merle A.; Drescher, Peter; Sparwasser, Christoph; Madsen, Paul O. (October 1994). "Isolation and biological activity of aspidospermine and quebrachamine from an Aspidosperma tree source". Journal of Pharmaceutical and Biomedical Analysis. 12 (10): 1283–1287.
doi:
10.1016/0731-7085(94)00066-2.
PMID7841224.
^Marino, Joseph P.; Rubio, Maria B.; Cao, Ganfeng; de Dios, Alfonso (November 2002). "Total Synthesis of (+)-Aspidospermidine: A New Strategy for the Enantiospecific Synthesis of Aspidosperma Alkaloids". Journal of the American Chemical Society. 124 (45): 13398–13399.
doi:
10.1021/ja026357f.
PMID12418888.
^Callaghan, Owen; Lampard, Christopher; Kennedy, Alan R.; Murphy, John A. (1999). "A novel total synthesis of (±)-aspidospermidine". Journal of the Chemical Society, Perkin Transactions 1 (8): 995–1002.
doi:
10.1039/A900335E.
^Anagnostaki, Elissavet E.; Zografos, Alexandros L. (2012). ""Common synthetic scaffolds" in the synthesis of structurally diverse natural products". Chemical Society Reviews. 41 (17): 5613–25.
doi:
10.1039/c2cs35080g.
PMID22782134.