| Combination of | |
|---|---|
| Aliskiren | Renin inhibitor |
| Amlodipine | Calcium channel blocker ( dihydropyridine) |
| Clinical data | |
| Trade names | Tekamlo, Rasilamlo |
| AHFS/ Drugs.com | Professional Drug Facts |
| License data | |
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Routes of administration | By mouth |
| ATC code | |
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The drug combination aliskiren/ amlodipine ( INNs, trade names Tekamlo and Rasilamlo) is an antihypertensive. Clinical trials have shown it to be more effective than amlodipine on its own, [1] with a high dosing regime (aliskiren 300 mg/amlodipine 10 mg) being more effective than olmesartan/amlodipine with comparable tolerability. [2]
References
- ^ Pfeiffer D, Rennie N, Papst CC, Zhang J (November 2012). "Efficacy and tolerability of aliskiren/amlodipine single-pill combinations in patients who did not respond fully to amlodipine monotherapy¥". Current Vascular Pharmacology. 10 (6): 773–80. doi: 10.2174/157016112803520945. PMID 22303911.
- ^ Axthelm C, Sieder C, Meister F, Kaiser E (January 2012). "Efficacy and tolerability of the single-pill combination of aliskiren 300 mg/amlodipine 10 mg in hypertensive patients not controlled by olmesartan 40 mg/amlodipine 10 mg". Current Medical Research and Opinion. 28 (1): 69–78. doi: 10.1185/03007995.2011.637914. PMID 22117838. S2CID 25693979.
Further reading
- "FDA Drug Safety Communication: New Warning and Contraindication for blood pressure medicines containing aliskiren (Tekturna)". U.S. Food and Drug Administration. 19 January 2016.
External links
- "Aliskiren mixture with amlodipine". Drug Information Portal. U.S. National Library of Medicine.
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