In December 2020, a follow up to Alexander and the Terrible, Horrible, No Good, Very Bad Day was announced to be in early development for
Disney+ with Matt Lopez writing the script. The sequel would follow a similar plot applied to a "multi-generational Latinx family".
21 Laps Entertainment and the
Jim Henson Company are also set to return.[1] On October 4, 2022, Marvin Lemus was chosen as the director, while
Eva Longoria and
George Lopez were cast as Alexander's parents.[2] In February 2023, Jesse Garcia joined the cast.[3] In March, Thom Nemer was cast in the lead role as Alexander Cooper.[4] The same month, Paulina Chávez and Rose Portillo joined the cast.[5] In April, George Lopez was replaced by
Cheech Marin due to scheduling conflicts.[6][7] The same month,
Cristo Fernández and
Harvey Guillén joined the cast.[8][9]
Production began in April 2023 in
New Mexico.[2][8][9] By March 2024, the film's title had changed to Alexander and the Terrible, Horrible, No Good, Very Bad Road Trip.[10]