From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Autophagy-related protein 9A is a
protein that in humans is encoded by the ATG9A
gene .
[5]
Functional studies indicate that ATG9A plays a role in
autophagy .
[6]
[7] and other non-autophagy membrane remodeling processes such as
plasma membrane repair.
[8] Enzymatically, it is a lipid
scramblase .
[6]
[7] ATG9A interacts with
IQGAP1 and the
ESCRT machinery in membrane remodeling.
[8]
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000198925 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000033124 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Entrez Gene: ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae)" .
^
a
b Maeda S, Yamamoto H, Kinch LN, Garza CM, Takahashi S, Otomo C, et al. (December 2020).
"Structure, lipid scrambling activity and role in autophagosome formation of ATG9A" . Nature Structural & Molecular Biology . 27 (12): 1194–1201.
doi :
10.1038/s41594-020-00520-2 .
PMC
7718406 .
PMID
33106659 .
^
a
b Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, et al. (December 2020). "Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion". Nature Structural & Molecular Biology . 27 (12): 1185–1193.
doi :
10.1038/s41594-020-00518-w .
PMID
33106658 .
S2CID
225081989 .
^
a
b Claude-Taupin A, Jia J, Bhujabal Z, Garfa-Traoré M, Kumar S, da Silva GP, et al. (July 2021).
"ATG9A protects the plasma membrane from programmed and incidental permeabilization" . Nature Cell Biology . 23 (8): 846–858.
doi :
10.1038/s41556-021-00706-w .
ISSN
1465-7392 .
PMC
8276549 .
PMID
34257406 .
Hartley JL, Temple GF, Brasch MA (November 2000).
"DNA cloning using in vitro site-specific recombination" . Genome Research . 10 (11): 1788–95.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001).
"Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . Genome Research . 11 (3): 422–35.
doi :
10.1101/gr.GR1547R .
PMC
311072 .
PMID
11230166 .
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, et al. (September 2004).
"Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Research . 14 (9): 1711–8.
doi :
10.1101/gr.2435604 .
PMC
515316 .
PMID
15342556 .
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004).
"From ORFeome to biology: a functional genomics pipeline" . Genome Research . 14 (10B): 2136–44.
doi :
10.1101/gr.2576704 .
PMC
528930 .
PMID
15489336 .
Yamada T, Carson AR, Caniggia I, Umebayashi K, Yoshimori T, Nakabayashi K, Scherer SW (May 2005).
"Endothelial nitric-oxide synthase antisense (NOS3AS) gene encodes an autophagy-related protein (APG9-like2) highly expressed in trophoblast" . The Journal of Biological Chemistry . 280 (18): 18283–90.
doi :
10.1074/jbc.M413957200 .
PMID
15755735 .
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006).
"The LIFEdb database in 2006" . Nucleic Acids Research . 34 (Database issue): D415-8.
doi :
10.1093/nar/gkj139 .
PMC
1347501 .
PMID
16381901 .
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48.
doi :
10.1016/j.cell.2006.09.026 .
PMID
17081983 .
S2CID
7827573 .