Tether containing UBX domain for GLUT4 (TUG) is a
protein that in humans is encoded by the ASPSCR1gene.[5][6][7]
This gene is a candidate gene for
alveolar soft part sarcoma (ASPS). It has been found that ASPSCR1 can undergo oncogenic rearrangement with transcription factor
TFE3 gene, creating an aberrant gene that is a stronger transcriptional
activator than TFE3 alone.[8] This fusion oncogene encodes for a chimeric
transcription factor, which is responsible for the production of multiple molecules that contribute to ASPS and also to
renal cell carcinomas.[9] Several alternatively spliced transcript variants of this gene have been described, but their full length nature has not been determined.[7]
^Lazar AJ, Lahat G, Myers SE, Smith KD, Changye Z, Wei-Lien W, Lopez-Terrada D, Lev D (Dec 2009). "Validation of potential therapeutic targets in alveolar soft part sarcoma: an immunohistochemical study utilizing tissue microarray". Histopathology. 55 (6): 750–755.
doi:
10.1111/j.1365-2559.2009.03436.x.
PMID20002771.
S2CID23287961.
Heimann P, El Housni H, Ogur G, et al. (2001). "Fusion of a novel gene, RCC17, to the TFE3 gene in t(X;17)(p11.2;q25.3)-bearing papillary renal cell carcinomas". Cancer Res. 61 (10): 4130–5.
PMID11358836.