From Wikipedia, the free encyclopedia
Protein
AT-rich interactive domain-containing protein 4B is a
protein that in humans is encoded by the ARID4B
gene.
[5]
[6]
This gene encodes a protein with sequence similarity to
retinoblastoma-binding protein-1. The encoded protein is a subunit of the
histone deacetylase-dependent
SIN3A transcriptional
corepressor complex, which functions in diverse cellular processes including
proliferation,
differentiation,
apoptosis,
oncogenesis, and
cell fate determination. The gene product is recognized by
IgG
antibody isolated from a
breast cancer patient and appears to be a
molecular marker associated with a broad range of human malignancies. Alternate transcriptional
splice variants encoding different
isoforms have been characterized.
[6]
- Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI (2002).
"Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11.
doi:
10.1016/S0960-9822(01)00650-9.
PMID
11790298.
S2CID
14132033.
- Bommel H, Xie G, Rossoll W, Wiese S, Jablonka S, Boehm T, Sendtner M (2003).
"Missense mutation in the tubulin-specific chaperone E (Tbce) gene in the mouse mutant progressive motor neuronopathy, a model of human motoneuron disease". J. Cell Biol. 159 (4): 563–9.
doi:
10.1083/jcb.200208001.
PMC
2173089.
PMID
12446740.
- Fleischer TC, Yun UJ, Ayer DE (2003).
"Identification and characterization of three new components of the mSin3A corepressor complex". Mol. Cell. Biol. 23 (10): 3456–67.
doi:
10.1128/MCB.23.10.3456-3467.2003.
PMC
164750.
PMID
12724404.
- Cui D, Jin G, Gao T, Sun T, Tian F, Estrada GG, Gao H, Sarai A (2004).
"Characterization of BRCAA1 and its novel antigen epitope identification". Cancer Epidemiol. Biomarkers Prev. 13 (7): 1136–45.
doi:
10.1158/1055-9965.1136.13.7.
PMID
15247124.
S2CID
28408982.
- Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5.
Bibcode:
2004PNAS..10112130B.
doi:
10.1073/pnas.0404720101.
PMC
514446.
PMID
15302935.
- Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006).
"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48.
doi:
10.1016/j.cell.2006.09.026.
PMID
17081983.
S2CID
7827573.