Amyloid beta A4 precursor protein-binding family B member 3 is a
protein that in humans is encoded by the APBB3gene.[5][6]
The protein encoded by this gene is a member of the APBB protein family. It is found in the
cytoplasm and binds to the
intracellular domain of the
Alzheimer's disease
beta-amyloid precursor protein (APP) as well as to other APP-like proteins. It is thought that the protein encoded by this gene may modulate the
internalization of APP. Multiple
transcript variants encoding several different
isoforms have been found for this gene.[6]
Tanahashi H, Tabira T (1999). "Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein". Neurosci. Lett. 261 (3): 143–6.
doi:
10.1016/S0304-3940(98)00995-1.
PMID10081969.
S2CID54307954.
Tanahashi H, Tabira T (1999). "Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein". Biochem. Biophys. Res. Commun. 258 (2): 385–9.
doi:
10.1006/bbrc.1999.0639.
PMID10329396.