From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Anaphase-promoting complex subunit 1 is an
enzyme that in humans is encoded by the ANAPC1
gene .
[5]
[6]
ANAPC1 is one of at least ten subunits of the
anaphase-promoting complex (APC), which functions at the
metaphase -to-
anaphase transition of the
cell cycle and is regulated by
spindle checkpoint proteins. The APC is an
E3 ubiquitin ligase that targets cell cycle regulatory proteins for degradation by the
proteasome , thereby allowing progression through the cell cycle (supplied by
OMIM ).
[6]
Interactions
ANAPC1 has been shown to
interact with
ANAPC5 ,
[7]
[8]
ANAPC4 ,
[7]
[8]
ANAPC2 ,
[7]
[8]
CDC27
[7]
[8] and
ANAPC7 .
[7]
[8]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000153107 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000014355 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Jorgensen PM, Graslund S, Betz R, Stahl S, Larsson C, Hoog C (February 2001). "Characterisation of the human APC1, the largest subunit of the anaphase-promoting complex". Gene . 262 (1–2): 51–9.
doi :
10.1016/S0378-1119(00)00511-4 .
PMID
11179667 .
^
a
b
"Entrez Gene: ANAPC1 anaphase promoting complex subunit 1" .
^
a
b
c
d
e Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003).
"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68.
Bibcode :
2003CBio...13.1459V .
doi :
10.1016/S0960-9822(03)00581-5 .
ISSN
0960-9822 .
PMID
12956947 .
S2CID
5942532 .
^
a
b
c
d
e Sumara I, Vorlaufer E, Gieffers C, Peters B H, Peters J M (November 2000).
"Characterization of vertebrate cohesin complexes and their regulation in prophase" . J. Cell Biol . 151 (4): 749–62.
doi :
10.1083/jcb.151.4.749 .
ISSN
0021-9525 .
PMC
2169443 .
PMID
11076961 .
External links
Further reading
Grossberger R, Gieffers C, Zachariae W, et al. (1999).
"Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex" . J. Biol. Chem . 274 (20): 14500–7.
doi :
10.1074/jbc.274.20.14500 .
PMID
10318877 .
Gieffers C, Peters BH, Kramer ER, et al. (1999).
"Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons" . Proc. Natl. Acad. Sci. U.S.A . 96 (20): 11317–22.
Bibcode :
1999PNAS...9611317G .
doi :
10.1073/pnas.96.20.11317 .
PMC
18031 .
PMID
10500174 .
Gmachl M, Gieffers C, Podtelejnikov AV, et al. (2000).
"The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proc. Natl. Acad. Sci. U.S.A . 97 (16): 8973–8.
Bibcode :
2000PNAS...97.8973G .
doi :
10.1073/pnas.97.16.8973 .
PMC
16806 .
PMID
10922056 .
Zur A, Brandeis M (2001).
"Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis" . EMBO J . 20 (4): 792–801.
doi :
10.1093/emboj/20.4.792 .
PMC
145417 .
PMID
11179223 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Vodermaier HC, Gieffers C, Maurer-Stroh S, et al. (2004).
"TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Curr. Biol . 13 (17): 1459–68.
Bibcode :
2003CBio...13.1459V .
doi :
10.1016/S0960-9822(03)00581-5 .
PMID
12956947 .
S2CID
5942532 .
Kraft C, Herzog F, Gieffers C, et al. (2004).
"Mitotic regulation of the human anaphase-promoting complex by phosphorylation" . EMBO J . 22 (24): 6598–609.
doi :
10.1093/emboj/cdg627 .
PMC
291822 .
PMID
14657031 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004).
"Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proc. Natl. Acad. Sci. U.S.A . 101 (33): 12130–5.
Bibcode :
2004PNAS..10112130B .
doi :
10.1073/pnas.0404720101 .
PMC
514446 .
PMID
15302935 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Nousiainen M, Silljé HH, Sauer G, et al. (2006).
"Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391–6.
Bibcode :
2006PNAS..103.5391N .
doi :
10.1073/pnas.0507066103 .
PMC
1459365 .
PMID
16565220 .