4-trimethylaminobutyraldehyde dehydrogenase is an
enzyme that in humans is encoded by the ALDH9A1gene.[5][6][7]
Function
This protein belongs to the
aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to
gamma-aminobutyric acid (GABA). This isozyme is a
tetramer of identical 54-kD subunits.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Human Genetics. 93 (2): 211–2.
doi:
10.1007/bf00210615.
PMID8112751.
S2CID26773065.
Izaguirre G, Kikonyogo A, Pietruszko R (September 1997). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 118 (1): 59–64.
doi:
10.1016/s0305-0491(97)00022-9.
PMID9417993.