A-kinase anchor protein 12, aka AKAP250, is an
enzyme that in humans is encoded by the AKAP12gene.[5][6]
Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of
protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in
endothelial cells, cultured
fibroblasts, and
osteosarcoma cells. It associates with
protein kinase A and
C and
phosphatase, and serves as a scaffold protein in
signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[6]
Yildirim M, Paydas S, Tanriverdi K, Seydaoglu G, Disel U, Yavuz S (2007). "Gravin gene expression in acute leukaemias: clinical importance and review of the literature". Leuk. Lymphoma. 48 (6): 1167–72.
doi:
10.1080/10428190701377055.
PMID17577780.
S2CID35975874.
Sato N, Kokame K, Shimokado K, Kato H, Miyata T (1998). "Changes of gene expression by lysophosphatidylcholine in vascular endothelial cells: 12 up-regulated distinct genes including 5 cell growth-related, 3 thrombosis-related, and 4 others". J. Biochem. 123 (6): 1119–26.
doi:
10.1093/oxfordjournals.jbchem.a022051.
PMID9604001.
Grove BD, Bruchey AK (2001). "Intracellular distribution of gravin, a PKA and PKC binding protein, in vascular endothelial cells". J. Vasc. Res. 38 (2): 163–75.
doi:
10.1159/000051043.
PMID11316952.
S2CID6002979.
Sasaki H, Kunimatsu M, Fujii Y, Yamakawa Y, Fukai I, Kiriyama M, Nonaka M, Sasaki M (2001). "Autoantibody to gravin is expressed more strongly in younger and nonthymomatous patients with myasthenia gravis". Surg. Today. 31 (11): 1036–7.
doi:
10.1007/s005950170020.
PMID11766078.
S2CID22167880.