This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a
propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by
ADAMTS19, another family member. The function of this protein has not been determined. [provided by RefSeq, Jul 2008].
Peters BJ, Rodin AS, Klungel OH, Stricker BH, de Boer A, Maitland-van der Zee AH (December 2010). "Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction". Pharmacogenetics and Genomics. 20 (12): 766–774.
doi:
10.1097/FPC.0b013e328340aded.
PMID21037509.
S2CID23007611.
Cal S, Obaya AJ, Llamazares M, Garabaya C, Quesada V, López-Otín C (January 2002). "Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains". Gene. 283 (1–2): 49–62.
doi:
10.1016/s0378-1119(01)00861-7.
PMID11867212.
Khan AO, Aldahmesh MA, Al-Ghadeer H, Mohamed JY, Alkuraya FS (December 2012). "Familial spherophakia with short stature caused by a novel homozygous ADAMTS17 mutation". Ophthalmic Genetics. 33 (4): 235–239.
doi:
10.3109/13816810.2012.666708.
PMID22486325.
S2CID37291964.