50 series may refer to:
- HP 49/50 series, a type of graphing calculator made by Hewlett-Packard
- 1–50 series (CTA), a retired subway car type for the Chicago Transit Authority
- EMD SD50, also known as "50 series", a North American diesel locomotive type made by Electro-Motive Diesel
- Kyoto Municipal Subway 50 series operating for the Kyoto Municipal Subway
- Dodge 50 Series, a box truck model operating in Europe
- Detroit Diesel Series 50, a diesel engine for heavy-duty vehicles
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