3-Allylfentanyl[2] has effects similar to fentanyl, although it is only 0.13x-0.14x as potent by weight.[3]
The decreased potency of this analogue caused by the addition of the allyl group makes it somewhat less dangerous than fentanyl itself (ED50(rat) of 80μg/kg vs 11μg/kg for fentanyl), although this is relative.[3] For comparison,
carfentanil is at least 20-30x as potent as fentanyl.
Side Effects
Side effects of
fentanyl analogs vary based on strength and are similar to those of fentanyl itself, which include
itching,
nausea and potentially serious
respiratory depression, which can be life-threatening.
^Drug Enforecement Administration, Department of Justice (February 2018). "Schedules of Controlled Substances:Temporary Placement of Fentanyl-Related Substances in Schedule I. Temporary amendment; temporary scheduling order". Federal Register. 83 (25): 5188–92.
PMID29932611.
^US Expired USRE33495E, Linas V. Kudzma, H. Kenneth Spencer, Sherry A. Savernak, "Stereoselective preparation of 3-substituted-4-anilino-piperidine compounds and derivatives", published 1990-12-18, issued 1990-12-18, assigned to Anaquest, INC. A DE Corporation