From Wikipedia, the free encyclopedia
β-Melanocyte-stimulating hormone
Names
Other names
beta-MSH, β-melanotropin, β-melanocortin, β-intermedin
Identifiers
CC(C(=O)NC(CCC(=O)O)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)N1CCCC1C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NC(CC3=CNC=N3)C(=O)NC(CC4=CC=CC=C4)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC5=CNC6=CC=CC=C65)C(=O)NCC(=O)NC(CO)C(=O)N7CCCC7C(=O)N8CCCC8C(=O)NC(CCCCN)C(=O)NC(CC(=O)O)C(=O)O)N
Properties
C 118 H 174 N 34 O 35 S
Molar mass
2660 .95 g·mol−1
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
β-Melanocyte-stimulating hormone (β-MSH ) is an
endogenous
peptide hormone and
neuropeptide .
[1] It is a
melanocortin , specifically, one of the three types of
melanocyte-stimulating hormone (MSH), and is produced from
proopiomelanocortin (POMC).
[1] It is an
agonist of the
MC1 ,
MC3 ,
MC4 , and
MC5 receptors .
[1]
β-MSH is artificially generated because it does not exist in humans naturally.[
contradictory ]
[2]
β-MSH is also known to decrease food intake in animals such as rats, chicken due to the effect of
proopiomelanocortin (POMC).
[3] Research was performed to see the effect β-MSH has on chicks, and it has been found that chicks responded with a decrease in food and water intake when treated with β-MSH. The experiment showed that β-MSH causes anorexigenic effects in chicks.
[4]
See also
References
^
a
b
c Abba Kastin (26 January 2013).
Handbook of Biologically Active Peptides . Academic Press. pp. 838–844.
ISBN
978-0-12-385096-6 .
^ Bertagna, X; Lenne, F; Comar, D; Massias, J F; Wajcman, H; Baudin, V; Luton, J P; Girard, F (December 1986).
"Human beta-melanocyte-stimulating hormone revisited" . Proceedings of the National Academy of Sciences of the United States of America . 83 (24): 9719–9723.
Bibcode :
1986PNAS...83.9719B .
doi :
10.1073/pnas.83.24.9719 .
ISSN
0027-8424 .
PMC
387212 .
PMID
2432601 .
^ Kamisoyama, Hiroshi; Honda, Kazuhisa; Saneyasu, Takaoki; Sugahara, Kunio; Hasegawa, Shin (2009-07-24). "Corticotropin-releasing factor is a downstream mediator of the beta-melanocyte-stimulating hormone-induced anorexigenic pathway in chicks". Neuroscience Letters . 458 (3): 102–105.
doi :
10.1016/j.neulet.2009.04.041 .
ISSN
0304-3940 .
PMID
19393716 .
S2CID
42981014 .
^ Smith, M. L.; Prall, B.; Nandar, W.; Cline, M. A. (February 2008). "Beta-melanocyte-stimulating hormone potently reduces appetite via the hypothalamus in chicks". Journal of Neuroendocrinology . 20 (2): 220–226.
doi :
10.1111/j.1365-2826.2007.01639.x .
ISSN
1365-2826 .
PMID
18088360 .
S2CID
19661927 .